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Chronic cor pulmonale due to multiple pulmonary emboli and accompanied by diffuse interstitial fibrosis

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      Abstract

      • 1.
        1. A patient with cor pulmonale with progressive right ventricular failure due to multiple emboli is reported.
      • 2.
        2. A secondary feature was a spotty interstitial fibrosis first discovered by lung biopsy and confirmed at autopsy.
      • 3.
        3. The cause of the interstitial fibrosis and its relationship to the vascular occlusion is discussed.
      • 4.
        4. Studies which may be helpful in establishing the diagnosis of this disorder are listed.
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      References

        • Owen W.R.
        • Thomas W.A.
        • Castleman B.
        • Bland E.F.
        Unrecognized emboli to lungs with subsequent cor pulmonale.
        New England J. Med. 1953; 249: 919
        • Carol D.
        Chronic obstruction of major pulmonary arteries.
        Am. J. Med. 1950; 9: 175
        • Belt T.H.
        Late sequelae of pulmonary embolism.
        Lancet. 1939; 237: 730
        • Petch C.P.
        Cor pulmonale from recurrent pulmonary embolism.
        Lancet. 1951; 1: 1346
        • Barr J.R.
        • Knox Jr., F.H.
        Embolic obstruction of major pulmonary arteries producing chronic cor pulmonale.
        Dis. of Chest. 1956; 29: 225
        • Davison P.H.
        • Armitage G.H.
        • McIlveen D.J.
        Chronic cor pulmonale due to silent pulmonary embolism.
        Lancet. 1956; 27: 224
      1. New England J. Med. 1957; 256: 850
        • Lenegre J.
        • Gerbaux A.
        • Subat L.
        • Leconte de Floris R.
        Four new observations of chronic cor pulmonale caused by pulmonary arterial thrombosis. A clinical and hemodynamic study.
        Arch. d. mal. du coeur. 1955; 48: 1132
      2. Cor pulmonale complicated by multiple pulmonary emboli.
        in: Clinical Pathological Conference. Ann. Int. Med.38. 1953: 878
        • Leinassar J.M.
        • Niles N.R.
        Massive occlusion of the main pulmonary artery and primary branches.
        Circulation. 1958; 17: 60
        • Castleman B.
        Healed pulmonary infarcts.
        Arch. Path. 1940; 30: 130
        • Hamman L.
        • Rich A.R.
        Fulminating diffuse interstitial fibrosis of lungs.
        Tr. Am. Climat. & Clin. A. 1935; 51: 154
        • Hamman L.
        • Rich A.R.
        Acute diffuse interstitial fibrosis of the lungs.
        Bull. Johns Hopkins Hosp. 1944; 74: 177
        • Hippleston A.G.
        Chronic diffuse interstitial fibrosis of lungs.
        Thorax. 1951; 6: 426
        • Cox T.R.
        • Kohl J.M.
        Diffuse fibrosing interstitial pneumonitis.
        Am. J. Clin. Path. 1952; 22: 770
        • Callahan Jr., W.P.
        • Sutherland J.C.
        • Fulton J.K.
        • Kline J.P.
        Acute diffuse interstitial fibrosis of lungs.
        Arch. Int. Med. 1952; 90: 468
        • Ogilivie A.G.
        • Hulse E.V.
        Diffuse interstitial fibrosis of lungs: case.
        Brit. J. Tuber. 1954; 48: 200
      3. Clinical pathological conferences: case records Massachusetts General Hospital. New England J. Med.252. 1955: 32
        • Peabody J.W.
        • Peabody Jr., J.W.
        Diffuse fibrosing interstitial pneumonitis (Hamman-Rich syndrome).
        Dis. of Chest. 1955; 26: 709
        • Pokorny C.
        • Hellwig G.A.
        Diffuse interstitial fibrosis of lungs.
        Arch. Path. 1955; 59: 382
        • Katz S.
        Diffuse interstitial fibrosis of lungs (Hamman-Rich syndrome).
        GP. 1955; 12: 81
        • Pinney C.T.
        • Harris H.W.
        Hamman-Rich syndrome.
        Am. J. Med. 1956; 20: 308
        • Grant I.W.
        • Hillis B.R.
        • Davidson J.
        Diffuse interstitial fibrosis of lungs (Hamman-Rich syndrome).
        Am. Rev. Tuberc. 1956; 74: 485
        • Cross K.R.
        Diffuse interstitial pneumonitis acute, fibrosis, and focal healing patterns.
        Arch. Path. 1957; 63: 132
        • White R.B.
        • Craighead J.J.
        Hamman-Rich syndrome.
        Dis. of Chest. 1957; 31: 335
        • Silverman J.J.
        • Talbot T.J.
        Case report: diffuse interstitial pulmonary fibrosis camouflaged by hypermetabolism and cardiac failure.
        Ann. Int. Med. 1953; 38: 1326
        • King S.D.
        Diffuse pulmonary lesions.
        Bull. New England M. Center. 1949; 11: 43
        • Andrews Jr., E.C.
        Five cases of pulmonary interstitial fibrosis due to obstruction of pulmonary veins.
        Bull. Johns Hopkins Hosp. 1957; 100: 28
        • Mallory T.B.
        Pathology of pulmonary fibrosis, including chronic pulmonary sarcoidosis.
        Radiology. 1948; 5: 468
        • Brewer O.
        Pathology of the vessels of the pulmonary circulation.
        Arch. Int. Med. 1955; 56: 1220
        • Byrne J.J.
        • O'Neill E.E.
        Fatal pulmonary embolism.
        Am. J. Surg. 1952; 83: 47
      4. Am. J. Med. 1955; 19: 126
        • Black H.
        • Harken D.E.
        Current indications for surgical correction of mitral stenosis.
        Am. Heart J. 1957; 53: 444
        • Smith W.J.
        Roentgenographic aspects of complete and incomplete pulmonary infarction.
        Dis. of Chest. 1953; 23: 532
        • Hampton A.O.
        • Castleman B.
        Correlation of postmortem teleroentgenograms with autopsy findings, with special reference to pulmonary emboli and infarction.
        Am. J. Roentgenol. 1940; 43: 305
        • Atchison J.P.
        • McKay J.M.
        Pulmonary artery occlusion demonstrated by angiocardiography.
        Brit. J. Radiol. 1956; 29: 298
        • Dexter L.
        Pulmonary hypertension developing in atrial septal defect.
        in: Proceedings of the International Symposium on the Pulmonary Circulation, Chicago, Ill.March 20–22, 1958 (To be published)
        • Sherry S.
        • Fletcher D.P.
        • Alkjaersig N.
        Developments in fibrinolytic therapy for thromboembolic disease.
        in: Presented at the Thirty-Ninth Annual Session of the American College of Physicians, Atlantic City, N. J.April 29, 1958