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Abstract
Eighty subjects in whom there was no therapeutic indication for anticoagulant therapy
were given four prothrombinopenic agents, bishydroxycoumarin, diphenadione, phenindione
and warfarin. The onset of action of all four drugs was between the eighth and sixteenth
hour following the administration of a single large dose. The peak effect for phenindione
was obtained in thirty-two hours, and for the other three drugs in forty hours. The
extent of depression was reasonably uniform among subjects receiving the same drug
but the duration of effect was quite variable.
The findings suggest that an induction program consisting of a single large loading
dose followed by a maintenance dose might be practical and safe for all four drugs.
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References
- Clinical experience with the anticoagulant coumadin (warfarin) sodium.Angiology. 1957; 8: 302
- Comparative clinical study of coumadin sodium and dicumarol in patients with thromboembolic diseases.Am. Heart J. 1958; 55: 66
- Clinical experience with 3-(1-phenylpropyl)-4-hydroxycoumarin.in: Proc. Staff Meet., Mayo Clin.32. 1957: 342
- A comparison of some newer anticoagulants.Arch. Surg. 1956; 72: 153
- The choice of an anticoagulant.Am. J. M. Sc. 1954; 227: 526
- The control of excessive effect by anticoagulants.Ann. Int. Med. 1955; 43: 955
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© 1959 Published by Elsevier Inc.
