Paroxysmal nocturnal hemoglobinuria

I. Clinical studies
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      The clinical and laboratory findings in six patients with paroxysmal nocturnal hemoglobinuria are presented.
      Some unusual or little recognized features are discussed. These include occurrence of paroxysmal nocturnal hemoglobinuria in the Negro, presence of leg ulcers and skin lesions, hemorrhagic complications, and the development of iron deficiency.
      In accord with previous suggestions of others, a carefully planned program of rehabilitation is advocated, based on periodic outpatient transfusions of washed red cells.
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