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Abstract
- 1.1. Dibenamine (dibenzyl-β-chloroethyl-amine), a compound shown to possess certain sympatholytic properties in animals, was administered to fifty-four patients. Only the intravenous route was found to be safe and to yield consistent results. Given orally dibenamine was poorly tolerated and its action was unpredictable.
- 2.2. The effective single intravenous dose appeared to be 4 to 6 mg./Kg. bodyweight (0.25 to 0.50 Gm. per patient). The height of the pharmacological action of dibenamine usually occurred during the first twenty-four hours. In some patients the response to standard sympathetic stimuli appeared to be changed for several days following a single injection.
- 3.3. Following the administration of dibenamine, it was seen that some of the excitatory effects of sympathin released by stimulation of the adrenergic system were altered and appeared completely blocked when tested in the resting patient, following standard exercises or upon the intravenous injection of sympathomimetic compounds. Some of the expected responses to parenterally administered epinephrine remained unchanged or appeared potentiated by dibenamine.
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Article info
Footnotes
☆Part of this investigation was supported by grants from the Fluid Research Fund of the Rockefeller Foundation, the Utah Copper Company Research Fund and the Physicians Research Fund of the University of Utah. Read, in part, at the Meeting of the Western Society for Clinical Research, San Francisco, Calif., November 1, 1946.
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© 1947 Published by Elsevier Inc.
