- 1.1. Dibenamine (dibenzyl-β-chloroethyl-amine), a compound shown to possess certain sympatholytic properties in animals, was administered to fifty-four patients. Only the intravenous route was found to be safe and to yield consistent results. Given orally dibenamine was poorly tolerated and its action was unpredictable.
- 2.2. The effective single intravenous dose appeared to be 4 to 6 mg./Kg. bodyweight (0.25 to 0.50 Gm. per patient). The height of the pharmacological action of dibenamine usually occurred during the first twenty-four hours. In some patients the response to standard sympathetic stimuli appeared to be changed for several days following a single injection.
- 3.3. Following the administration of dibenamine, it was seen that some of the excitatory effects of sympathin released by stimulation of the adrenergic system were altered and appeared completely blocked when tested in the resting patient, following standard exercises or upon the intravenous injection of sympathomimetic compounds. Some of the expected responses to parenterally administered epinephrine remained unchanged or appeared potentiated by dibenamine.
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- Pharmacological properties of a new adrenergic blocking agent: N, N-dibenzyl-β-chloroethyl-amine (dibenamine).J. Pharmacol. & Exper. Therap. 1947; 89: 167
- The biological actions and therapeutic applications of the β-chloroethyl-amines and Sulfides.Science. 1946; 103: 409
- The late effects of bilateral carotid sinus denervation in man.J. Clin. Investigation. 1938; 17: 385
- Orthostatic tachycardia and orthostatic hypotension: Defects in the return of venous blood to the heart.Am. Heart J. 1944; 27: 145
- The Milroy Lectures on Respiratory Efficiency in Relation to Health and Disease.Lancet. 1921; 201: 593
- The Milroy Lectures on Respiratory Efficiency in Relation to Health and Disease.Lancet. 1921; 201: 637
- The Milroy Lectures on Respiratory Efficiency in Relation to Health and Disease.Lancet. 1921; 201: 693
- The Milroy Lectures on Respiratory Efficiency in Relation to Health and Disease.Lancet. 1921; 201: 741
- Range of blood pressure in hypertension.J. A. M. A. 1946; 130: 325
- The breath-holding test. A simple standard stimulus of blood pressure.Arch. Int. Med. 1939; 63: 899
- A standard stimulus for measuring vasomotor reactions: Its application in the study of hypertension.in: Proc. Staff Meet., Mayo Clin.7. 1932: 332
- The cardiocirculatory effects in man of neosynephrin.J. Clin. Investigation. 1942; 21: 1
- The effect of paredrine on the venous system.J. Clin. Investigation. 1940; 19: 503
- Mechanism of arterial hypertension induced by paredrinol.J. Clin. Investigation. 1939; 18: 439
Hecht, H., Daines, M. and Balberer, H. (to be published).
- The blood pressure response to epinephrine administered I.V. to subjects with normal blood pressure and to patients with essential hypertension.Am. Heart J. 1938; 16: 66
- Studies on epinephrine. III. Effect of epinephrine on the electrocardiogram of patients with “irritable heart.”.Arch. Int. Med. 1919; 24: 284
- Rhythmic property of the human heart.Arch. Int. Med. 1943; 72: 613
- Can variations in ventricular systole be determined from electro-cardiogram deflections?.J. Lab. & Clin. Med. 1924; 9: 217
- Studies on the cardiodynamic actions of drugs. II. The mechanism of cardiac stimulation by epinephrine.J. Pharmacol. & Exper. Therap. 1927; 30: 233
- The duration of systole in hypocalcemia.Am. Heart J. 1937; 14: 82
- The action of tetraethyl ammonium on the mammalian circulation.J. Pharmacol. & Exper. Therap. 1946; 87: 220
- Studies on conditions of activity in endocrine organs; sympathin E and sympathin I.Am. J. Physiol. 1933; 104: 557
☆Part of this investigation was supported by grants from the Fluid Research Fund of the Rockefeller Foundation, the Utah Copper Company Research Fund and the Physicians Research Fund of the University of Utah. Read, in part, at the Meeting of the Western Society for Clinical Research, San Francisco, Calif., November 1, 1946.