Investigations of the cerebrospinal fluid in cases of rheumatoid arthritis

      This paper is only available as a PDF. To read, Please Download here.


      The spinal fluid was examined in 141 cases of rheumatoid arthritis, thirty-eight men and 103 women, of whom fifty-eight (41 per cent) exhibited a protein content that was pathological in one way or other, fifteen (14 per cent) gave a pathological gold-sol reaction and seven showed an increased spinal fluid cell count. Altogether sixty-six cases (46.8 per cent) were found to have spinal fluids which were pathologically altered in some way.
      Statistical examination of the results shows, inter alia, that in cases of rheumatoid arthritis the average spinal fluid globulin value is increased and the average spinal fluid albumin value lowered, resulting in a raised average globulin-albumin quotient. Further, it was shown that the abnormal increases in spinal fluid protein values are not dependent on the degree of severity of the arthritic disease process and are little affected by the duration of the disease.
      The frequency of increased cell counts in the spinal fluid appears to be somewhat greater in cases with elevated protein contents.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Eeg-Olofsson R.
        Nord. Med. 1944; 21: 296
        • Eeg-Olofsson R.
        Nord. Med. 1944; 22: 1092
        • Graber-Duvernay J.
        • Gerbay F.
        Les réactions du liquide céphalo-rachidien au cours des polyarthritis chroniques.
        Acta med. Scandinav. 1939; 100: 150
        • Gripvall E.
        Svensk Läkartidning. 1943; 8: 501
        • Izikowitz S.
        Methodical and clinical studies on total protein, globulin and albumin concentrations in lumbar fluid.
        1941 (Stockholm)
        • Kabat E.A.
        • Landow H.
        • Moore D.H.
        Electrophoretic patterns of concentrated cerebrospinal fluid.
        in: 5th ed. Proc. Soc. Exper. Biol. & Med.49. 1942: 260
        • Ludwig A.O.
        • Short C.L.
        • Bauer W.
        Rheumatoid arthritis as cause of increased cerebrospinal-fluid protein; study of 101 patients.
        New England J. Med. 1943; 228: 306
        • Olsson R.
        Nord. Med. 1944; 22: 1089
        • Sundelin F.
        Nord. Med. 1944; 21: 295
        • Wiberg G.
        Nord. Med. 1943; 20: 2084