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Antibacterial precipitating antibodies in Group A hemolytic streptococcus sore throat

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      Abstract

      • 1.
        1. Purified c carbohydrate and a nontype-specific “x” substance present in acid extracts of Group A hemolytic streptococcal cells have been used in precipitin tests with human sera.
      • 2.
        2. Antibodies against one or the other or both of these antigens were demonstrable in the sera of certain cases of acute streptococcal sore throat at the onset of infection.
      • 3.
        3. An anti-c antibody response occurred in 6 per cent of the patients, and an anti-x antibody response occurred in 22 per cent of the men infected by Group A hemolytic streptococci.
      • 4.
        4. The presence or development of neither antibody could be correlated with any aspect of the acute suppurative phase of the illness.
      • 5.
        5. Poststreptococcal arthritis and pneumonitis occurred more frequently in infected men in whom anti-x antibody was demonstrable in the initial serum or during convalescence than in those in whom it was not present. A similar relationship was not discovered for anti-c precipitin.
      • 6.
        6. Anti-x antibody was infrequently discovered during the course of streptococcal respiratory disease complicated by late fever.
      • 7.
        7. It is suggested that the “x” substance may be the antigen responsible for serious streptococcal hypersensitivity.
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