- 1.1. A simple liver function test is described which is based on the presence of excessive excretion of benzoyl glucuronate in the urine after ingestion of 5 Gm. of benzoic acid. The test is non-toxic and can be performed quickly. In selected cases, when used in conjunction with the current liver tests, it has important diagnostic application.
- 2.2. The test was studied in twenty-three normal volunteers, in a control series of 100 patients who had no obvious hepatic disturbances, and in eighty-nine other patients in whom hepatic disturbances were suspected.
- 3.3. In all normal volunteers, and in patients without hepatic disturbances the test was negative.
- 4.4. In all cases of hepatitis and portal cirrhosis the test was positive.
- 5.5. The test was also positive in some patients with thyrotoxicosis and in most cases of hepatic metastasis. It was negative in all of nine lymphomas.
- 6.6. Application to two cases of early-type post-arsphenamine jaundice is described. In both cases hepatocellular damage was indicated by positive tests. In one the diagnosis of arsphenamine hepatitis was made in the presence of gallstones.
- 7.7. The glucuronate reactions remained negative in a patient with obstructive jaundice of very long standing.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
- Differences in excretion of hippuric acid and glucuronates after ingestion of sodium benzoate and benzoic acid.Am. J. Digest. Dis. 1946; 13: 275-278
- Increased excretion of glucuronates after ingestion of benzoic acid by patients with damaged liver.Am. J. Digest. Dis. 1946; 13: 341-344
- On the quantitative aspects of benzoyl glucuronate formation in normal individuals and in patients with liver disorders.Am. J. Med. 1947; 2: 327-333
- The application to urine of Tollens' naphthoresorcinol test for conjugated glucuronates.Biochem. J. 1935; 292: 2705-2709
- Postarsphenamine jaundice apparently due to obstruction of the intrahepatic biliary tract.J. A. M. A. 1940; 155: 263-271
- Obstructive type of jaundice caused by arsphenamine.Tr. Ass. Am. Physicians. 1940; 55: 179-182