Excretion of benzoyl glucuronate as a test of liver function

      This paper is only available as a PDF. To read, Please Download here.


      • 1.
        1. A simple liver function test is described which is based on the presence of excessive excretion of benzoyl glucuronate in the urine after ingestion of 5 Gm. of benzoic acid. The test is non-toxic and can be performed quickly. In selected cases, when used in conjunction with the current liver tests, it has important diagnostic application.
      • 2.
        2. The test was studied in twenty-three normal volunteers, in a control series of 100 patients who had no obvious hepatic disturbances, and in eighty-nine other patients in whom hepatic disturbances were suspected.
      • 3.
        3. In all normal volunteers, and in patients without hepatic disturbances the test was negative.
      • 4.
        4. In all cases of hepatitis and portal cirrhosis the test was positive.
      • 5.
        5. The test was also positive in some patients with thyrotoxicosis and in most cases of hepatic metastasis. It was negative in all of nine lymphomas.
      • 6.
        6. Application to two cases of early-type post-arsphenamine jaundice is described. In both cases hepatocellular damage was indicated by positive tests. In one the diagnosis of arsphenamine hepatitis was made in the presence of gallstones.
      • 7.
        7. The glucuronate reactions remained negative in a patient with obstructive jaundice of very long standing.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Snapper I.
        • Greenspan E.
        • Saltzman A.
        Differences in excretion of hippuric acid and glucuronates after ingestion of sodium benzoate and benzoic acid.
        Am. J. Digest. Dis. 1946; 13: 275-278
        • Snapper I.
        • Saltzman A.
        • Greenspan E.
        Increased excretion of glucuronates after ingestion of benzoic acid by patients with damaged liver.
        Am. J. Digest. Dis. 1946; 13: 341-344
        • Snapper I.
        • Saltzman A.
        On the quantitative aspects of benzoyl glucuronate formation in normal individuals and in patients with liver disorders.
        Am. J. Med. 1947; 2: 327-333
        • Salt H.B.
        The application to urine of Tollens' naphthoresorcinol test for conjugated glucuronates.
        Biochem. J. 1935; 292: 2705-2709
        • Hanger F.M.
        • Gutman A.B.
        Postarsphenamine jaundice apparently due to obstruction of the intrahepatic biliary tract.
        J. A. M. A. 1940; 155: 263-271
        • Hanger F.M.
        • Gutman A.B.
        Obstructive type of jaundice caused by arsphenamine.
        Tr. Ass. Am. Physicians. 1940; 55: 179-182