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Diffuse lymphadenopathy as a manifestation of ankylosing spondylitis

  • Paul R. Marantz
    Correspondence
    Requests for reprints should be addressed to Dr. Paul R. Marantz, Department of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467.
    Affiliations
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, and the Department of Ambulatory Care, North Central Bronx Hospital, Bronx, New York, USA
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  • Mark Linzer
    Footnotes
    Affiliations
    Department of Medicine, Montefiore Medical Center and the Albert Einstein College of Medicine, and the Department of Ambulatory Care, North Central Bronx Hospital, Bronx, New York, USA
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  • Author Footnotes
    ∗ Current address: Division of General Internal Medicine, Duke University Medical Center, Durham, North Carolina.
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      Abstract

      Diffuse lymphadenopathy has not been previously described in association with ankylosing spondylitis. A 22-year-old man who presented with anorexia, weight loss, shoulder pain, and diffuse lymphadenopathy is described. Lymph node biopsy showed a nonspecific pattern of reactive hyperplasia with sinus histiocytosis. Clinical evaluation disclosed active spondylitis with HLA-B27 positivity. No other cause for the lymphadenopathy was found. The association between lymphadenopathy and connective tissue diseases is discussed. Ankylosing spondylitis should be added to the differential diagnosis of patients with generalized lymphadenopathy of uncertain cause.
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