The American Journal of Medicine
Volume 124, Issue 1 , Pages 40-47 , January 2011

Recent Trends in the Incidence, Treatment, and Outcomes of Patients with STEMI and NSTEMI

  • David D. McManus, MD, FACC

      Affiliations

    • Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester
    • Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester
  • ,
  • Joel Gore, MD, FACC

      Affiliations

    • Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester
  • ,
  • Jorge Yarzebski, MD, MPH

      Affiliations

    • Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester
  • ,
  • Frederick Spencer, MD

      Affiliations

    • Department of Medicine, McMaster University Medical School, Hamilton, Ontario, Canada
  • ,
  • Darleen Lessard, MS

      Affiliations

    • Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester
  • ,
  • Robert J. Goldberg, PhD

      Affiliations

    • Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester
    • Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester
    • Corresponding Author InformationRequests for reprints should be addressed to Robert J. Goldberg, PhD, Division of Epidemiology of Chronic Diseases and Vulnerable Populations, Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655

References 

  1. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined—a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36:959–969
  2. Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction—executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). Circulation. 2004;110:588–636
  3. Cox DA, Stone GW, Grines CL, et al. Comparative early and late outcomes after primary percutaneous coronary intervention in ST-segment elevation and non-ST-segment elevation acute myocardial infarction (from the CADILLAC trial). Am J Cardiol. 2006;98:331–337
  4. Abbott JD, Ahmed HN, Vlachos HA, et al. Comparison of outcome in patients with ST-elevation versus non-ST-elevation acute myocardial infarction treated with percutaneous coronary intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry). Am J Cardiol. 2007;100:190–195
  5. Mokdad AH, Bowman BA, Ford ES, et al. The continuing epidemics of obesity and diabetes in the United States. JAMA. 2001;286:195–200
  6. Floyd KC, Yarzebski J, Spencer FA, et al. A 30-year perspective (1975-2005) into the changing landscape of patients hospitalized with initial acute myocardial infarction: Worcester Heart Attack Study. Circ Cardiovasc Qual Outcomes. 2009;2:88–95
  7. Goodman SG, Steg PG, Eagle KA, et al. The diagnostic and prognostic impact of the redefinition of acute myocardial infarction: lessons from the Global Registry of Acute Coronary Events (GRACE). Am Heart J. 2006;151:654–660
  8. Goldberg RJ, Spencer FA, Okolo J, et al. Long-term trends (1986-2003) in the use of coronary reperfusion strategies in patients hospitalized with acute myocardial infarction in Central Massachusetts. Int J Cardiol. 2008;131:83–89
  9. McGovern PG, Jacobs DR, Shahar E, et al. Trends in acute coronary heart disease mortality, morbidity and medical care from 1985 through 1997: the Minnesota Heart Survey. Circulation. 2001;104:19–24
  10. Roger VL, Jacobsen SJ, Weston SA, et al. Trends in the incidence and survival of patients with hospitalized myocardial infarction (Olmsted County, Minnesota, 1979 to 1994). Ann Intern Med. 2002;136:341–348
  11. Ergin A, Muntner P, Sherwin H, He J. Secular trends in cardiovascular disease mortality, incidence, and case fatality rates in adults in the United States. Am J Med. 2004;117:219–227
  12. Rogers WJ, Canto JG, Lambrew CT, et al. Temporal trends in the treatment of over 1.5 million patients with myocardial infarction in the U.S. from 1990 through 1999. J Am Coll Cardiol. 2000;36:2056–2063
  13. Goldberg RJ, Gore JM, Alpert JS, Dalen JE. Recent changes in attack and survival rates of acute myocardial infarction (1975 through 1981) (The Worcester Heart Attack Study). JAMA. 1986;255:2774–2779
  14. Goldberg RJ, Spencer FA, Yarzebski J, et al. A 25-year perspective into the changing landscape of patients hospitalized with acute myocardial infarction (the Worcester Heart Attack Study). Am J Cardiol. 2004;94:1373–1378
  15. Goldberg RJ, Yarzebski J, Lessard D, Gore JM. Decade-long trends and factors associated with time to hospital presentation in patients with acute myocardial infarction: the Worcester Heart Attack study. Arch Intern Med. 2000;160:3217–3223
  16. Fox CS, Evans JC, Larson MG, et al. Temporal trends in coronary heart disease mortality and sudden cardiac death from 1950 to 1999: the Framingham Heart Study. Circulation. 2004;110:522–527
  17. Fox KA, Steg PG, Eagle KA, et al. Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006. JAMA. 2007;297:1892–1900
  18. Sprafka JM, Burke GL, Folsom AR, et al. Continued decline in cardiovascular disease risk factors: results of the Minnesota Heart Survey, 1980-1982 and 1985-1987. Am J Epidemiol. 1990;132:489–500
  19. Goch A, Misiewicz P, Rysz J, Banach M. The clinical manifestation of myocardial infarction in elderly patients. Clin Cardiol. 2009;32:E46–E51
  20. Parikh NI, Gona P, Larson MG, et al. Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study. Circulation. 2009;119:1203–1210
  21. Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction): developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation. 2007;116(7):e148–e304
  22. Chan MY, Sun JL, Newby LK, et al. Long-term mortality of patients undergoing cardiac catheterization for ST-elevation and non-ST-elevation myocardial infarction. Circulation. 2009;119:3110–3117
  23. Dziewierz A, Siudak Z, Rakowski T, et al. In-hospital management and mortality in elderly patients with non-ST-segment elevation acute coronary syndromes treated in centers without on-site invasive facilities. Cardiol J. 2008;15(5):451–457
  24. Krumholz HM, Radford MJ, Wang Y, et al. National use and effectiveness of beta-blockers for the treatment of elderly patients after acute myocardial infarction: National Cooperative Cardiovascular Project. JAMA. 1998;280:623–629
  25. Agarwal S, Bennett D, Smith DJ. Predictors of warfarin use in atrial fibrillation patients in the inpatient setting. Am J Cardiovasc Drugs. 2010;10:37–48
  26. Holmes DR. Cardiogenic shock: a lethal complication of acute myocardial infarction. Rev Cardiovasc Med. 2003;4:131–135
  27. Rogers WJ, Frederick PD, Stoehr E, et al. Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006. Am Heart J. 2008;156:1026–1034
  28. Setoguchi S, Glynn RJ, Avorn J, et al. Improvements in long-term mortality after myocardial infarction and increased use of cardiovascular drugs after discharge: a 10-year trend analysis. J Am Coll Cardiol. 2008;51:1247–1254
  29. Dziewierz A, Siudak Z, Rakowski T, et al. More aggressive pharmacological treatment may improve clinical outcome in patients with non-ST-elevation acute coronary syndromes treated conservatively. Coron Artery Dis. 2007;18:299–303

 Funding: National Institutes of Health (RO1 HL35434).

 Conflict of Interest: There are no conflicts of interest to report for any of the authors.

 Authorship: All authors had access to the data and had a role in writing this manuscript.

PII: S0002-9343(10)00736-9

doi: 10.1016/j.amjmed.2010.07.023

The American Journal of Medicine
Volume 124, Issue 1 , Pages 40-47 , January 2011