The American Journal of Medicine
Volume 123, Issue 9 , Pages 829-835 , September 2010

Obesity and Prostate Cancer Detection: Insights from Three National Surveys

  • Niyati Parekh, PhD, RD

      Affiliations

    • Department of Nutrition, Food Studies, and Public Health, New York University, New York
    • ,
  • Yong Lin, PhD

      Affiliations

    • The Cancer Institute of New Jersey, New Brunswick, NJ
    • School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, NJ
    • ,
  • Robert S. DiPaola, MD

      Affiliations

    • The Cancer Institute of New Jersey, New Brunswick, NJ
    • Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ
    • The Dean and Betty Gallo Prostate Cancer Center, New Brunswick, NJ
    • ,
  • Stephen Marcella, MD, MPH

      Affiliations

    • Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ
    • ,
  • Grace Lu-Yao, PhD, MPH

      Affiliations

    • The Cancer Institute of New Jersey, New Brunswick, NJ
    • School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, NJ
    • Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ
    • The Dean and Betty Gallo Prostate Cancer Center, New Brunswick, NJ
    • Corresponding Author InformationRequests for reprints should be addressed to Grace Lu-Yao, PhD, MPH, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, Room 5534, New Brunswick, NJ-08903

References 

  1. Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006;295:1549–1555
  2. Amling CL, Kane CJ, Riffenburgh RH, et al. Relationship between obesity and race in predicting adverse pathologic variables in patients undergoing radical prostatectomy. Urology. 2001;58:723–728
  3. Freedland SJ, Aronson WJ, Kane CJ, et al. Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the Shared Equal Access Regional Cancer Hospital database study group. J Clin Oncol. 2004;22:446–453
  4. Giovannucci E, Liu Y, Platz EA, et al. Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. Int J Cancer. 2007;121:1571–1578
  5. Wright ME, Chang SC, Schatzkin A, et al. Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality. Cancer. 2007;109:675–684
  6. Rodriguez C, Patel AV, Calle EE, et al. Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States. Cancer Epidemiol Biomarkers Prev. 2001;10:345–353
  7. O'Malley RL, Taneja SS. Obesity and prostate cancer. Can J Urol. 2006;13(Suppl 2):11–17
  8. Furuya Y, Akimoto S, Akakura K, Ito H. Smoking and obesity in relation to the etiology and disease progression of prostate cancer in Japan. Int J Urol. 1998;5:134–137
  9. Giovannucci E, Rimm EB, Stampfer MJ, et al. Height, body weight, and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 1997;6:557–563
  10. Shariat SF, Scardino PT, Lilja H. Screening for prostate cancer: an update. Can J Urol. 2008;15:4363–4374
  11. Thompson IM, Pauler DK, Goodman PJ, et al. Prevalence of prostate cancer among men with a prostate-specific antigen level<or=4.0 ng per milliliter. N Engl J Med. 2004;350:2239–2246
  12. Efstathiou JA, Chen MH, Catalona WJ, et al. Prostate-specific antigen-based serial screening may decrease prostate cancer-specific mortality. Urology. 2006;68:342–347
  13. Rundle A, Richards C, Neugut AI. Hemodilution of prostate-specific antigen levels among obese men. Cancer Epidemiol Biomarkers Prev. 2009;18:2343;author reply 2343-2344
  14. Ezzati TM, Massey JT, Waksberg J, et al. Sample design: Third National Health and Nutrition Examination Survey. Vital Health Stat 2. 1992;1–35
  15. Gunter EW, Lewis BG, Koncikowski SM. Laboratory Procedures Used for the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention; 1996;
  16. Third National Health and Examination Survey 1988-1994 documentation, codebook and frequencies Inhibin B, Luteinizing hormone, Testosterone. http://www.cdc.gov/nchs/data/nhanes/nh3data/htmAccessed April 30, 2010
  17. The World Health Organization Report. http://www.who.int/whr/2002/chapter4/en/index4.htmlAccessed April 30, 2010
  18. Centers for Disease Control and Prevention (CDC), National Center for Health Statistics. National Health and Nutrition Examination Survey (NHANES): Questionnaires, Examination Components, and Laboratory Components, 2003-2004. http://www.cdc.gov/nchs/nhanes/nhanes2003-2004/questexam03_04.htmAccessed April 30, 2010
  19. The National Health and Examination Survey 2003-2004 documentation on MEC Laboratory Component: Prostate Specific Antigen (PSA). http://www.cdc.gov/nchs/data/nhanes/nhanes_03_04/l11psa_c.pdfAccessed April 30, 2010
  20. Werny DM, Thompson T, Saraiya M, et al. Obesity is negatively associated with prostate-specific antigen in U.S. men, 2001-2004. Cancer Epidemiol Biomarkers Prev. 2007;16:70–76
  21. Division of Health Interview Statistics, National Center for Health Statistics. 2000 National Health Interview Survey (NHIS) Public Use Data Release: NHIS Survey Description. Hyattsville, MD: National Center for Health Statistics; 2002;
  22. Agresti A. Categorical Data Analysis. 2nd edition. Hoboken, NJ: Wiley; 2002;
  23. Osuna JA, Gomez-Perez R, Arata-Bellabarba G, Villaroel V. Relationship between BMI, total testosterone, sex hormone-binding-globulin, leptin, insulin and insulin resistance in obese men. Arch Androl. 2006;52:355–361
  24. Mohr BA, Bhasin S, Link CL, et al. The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. Eur J Endocrinol. 2006;155:443–452
  25. Gapstur SM, Kopp P, Gann PH, et al. Changes in BMI modulate age-associated changes in sex hormone binding globulin and total testosterone, but not bioavailable testosterone in young adult men: the CARDIA Male Hormone Study. Int J Obes (Lond). 2007;31:685–691
  26. Culp S, Porter M. The effect of obesity and lower serum prostate-specific antigen levels on prostate-cancer screening results in American men. BJU Int. 2009;104:1457–1461
  27. Lu-Yao G, Albertsen PC, Stanford JL, et al. Natural experiment examining impact of aggressive screening and treatment on prostate cancer mortality in two fixed cohorts from Seattle area and Connecticut. BMJ. 2002;325(7367):740
  28. Giovannucci E, Rimm EB, Liu Y, et al. Body mass index and risk of prostate cancer in U.S. health professionals. J Natl Cancer Inst. 2003;95:1240–1244
  29. MacInnis RJ, English DR, Gertig DM, et al. Body size and composition and prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 2003;12:1417–1421
  30. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625–1638
  31. Andersson SO, Wolk A, Bergstrom R, et al. Body size and prostate cancer: a 20-year follow-up study among 135006 Swedish construction workers. J Natl Cancer Inst. 1997;89:385–389
  32. Fesinmeyer MD, Gulati R, Zeliadt S, et al. Effect of population trends in body mass index on prostate cancer incidence and mortality in the United States. Cancer Epidemiol Biomarkers Prev. 2009;18:808–815
  33. Freedland SJ, Platz EA, Presti JC, et al. Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection. J Urol. 2006;175:500–504
  34. Freedland SJ, Platz EA. Obesity and prostate cancer: making sense out of apparently conflicting data. Epidemiol Rev. 2007;29:88–97
  35. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225–249
  36. Thompson IM, Ankerst DP, Chi C, et al. Assessing prostate cancer risk: results from the Prostate Cancer Prevention Trial. J Natl Cancer Inst. 2006;98:529–534

 Funding: This study was supported in part by Department of Defense award W81XWG-05-1-0235 and P30CA072720 and research funds from the Steinhardt School, New York University.

 Conflict of Interest: The authors declare that they have no competing interests.

 Authorship: All the authors verify having access to the data and have directly participated in the planning, execution, or analysis of this study.

PII: S0002-9343(10)00461-4

doi: 10.1016/j.amjmed.2010.05.011

The American Journal of Medicine
Volume 123, Issue 9 , Pages 829-835 , September 2010

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