The American Journal of Medicine
Volume 123, Issue 9 , Pages 829-835 , September 2010

Obesity and Prostate Cancer Detection: Insights from Three National Surveys

  • Niyati Parekh, PhD, RD

      Affiliations

    • Department of Nutrition, Food Studies, and Public Health, New York University, New York
    • ,
  • Yong Lin, PhD

      Affiliations

    • The Cancer Institute of New Jersey, New Brunswick, NJ
    • School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, NJ
    • ,
  • Robert S. DiPaola, MD

      Affiliations

    • The Cancer Institute of New Jersey, New Brunswick, NJ
    • Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ
    • The Dean and Betty Gallo Prostate Cancer Center, New Brunswick, NJ
    • ,
  • Stephen Marcella, MD, MPH

      Affiliations

    • Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ
    • ,
  • Grace Lu-Yao, PhD, MPH

      Affiliations

    • The Cancer Institute of New Jersey, New Brunswick, NJ
    • School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, NJ
    • Department of Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ
    • The Dean and Betty Gallo Prostate Cancer Center, New Brunswick, NJ
    • Corresponding Author InformationRequests for reprints should be addressed to Grace Lu-Yao, PhD, MPH, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, Room 5534, New Brunswick, NJ-08903

  • Image Result

    Design of the current study. The figure shows the variables available for each of the 3 study populations. BMI=Body Mass Index; PSA=prostate-specific antigen; NHANES=National Health and Nutrition Exam

    Design of the current study. The figure shows the variables available for each of the 3 study populations. BMI=Body Mass Index; PSA=prostate-specific antigen; NHANES=National Health and Nutrition Examination Survey; NIHS=National Health Interview Survey.

  • Image Result
    Mean±SE testosterone concentrations by Body Mass Index (BMI) groups in men aged 40+ years from the National Health and Nutrition Examination Survey III (1988-1994) population (n=845). The line graph d

    Mean±SE testosterone concentrations by Body Mass Index (BMI) groups in men aged 40+ years from the National Health and Nutrition Examination Survey III (1988-1994) population (n=845). The line graph demonstrates the mean testosterone±SE for each BMI category. There is a significant linear trend in mean testosterone with BMI categories (P for trend < .001).

  • Image Result
    The hypothesized mechanism for lower prostate cancer incidence among obese men. The figure illustrates the hypothesis that obese men are less likely to reach the biopsy threshold, possibly because of

    The hypothesized mechanism for lower prostate cancer incidence among obese men. The figure illustrates the hypothesis that obese men are less likely to reach the biopsy threshold, possibly because of lower testosterone concentrations, which in turn cause prostate-specific antigen (PSA) concentrations to be lower, ultimately resulting in lower biopsy rates and, therefore, lower incidence of prostate cancer.

 Funding: This study was supported in part by Department of Defense award W81XWG-05-1-0235 and P30CA072720 and research funds from the Steinhardt School, New York University.

 Conflict of Interest: The authors declare that they have no competing interests.

 Authorship: All the authors verify having access to the data and have directly participated in the planning, execution, or analysis of this study.

PII: S0002-9343(10)00461-4

doi: 10.1016/j.amjmed.2010.05.011

The American Journal of Medicine
Volume 123, Issue 9 , Pages 829-835 , September 2010

Article Tools

* Image Usage & Resolution