The American Journal of Medicine
Volume 123, Issue 8 , Pages 691-693 , August 2010

Celiac Disease Diagnosis: Simple Rules Are Better Than Complicated Algorithms

  • Carlo Catassi, MD, MPH

      Affiliations

    • Mucosal Biology Research and Center for Celiac Research, University of Maryland, School of Medicine, Baltimore
    • Universita' Politecnica delle Marche, Ancona, Italy
    • ,
  • Alessio Fasano, MD

      Affiliations

    • Mucosal Biology Research and Center for Celiac Research, University of Maryland, School of Medicine, Baltimore
    • Corresponding Author InformationRequests for reprints should be addressed to Alessio Fasano, MD, Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Health Science Facility II, Room S345, 20 Penn Street, Baltimore, MD 21201

References 

  1. Fasano A, Catassi C. Current approaches to the diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology. 2001;120:636–651
  2. Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005;40:1–19
  3. Revised criteria for diagnosis of celiac disease (Report of Working Group of European Society of Pediatric Gastroenterology and Nutrition). Arch Dis Child. 1990;65:909–911
  4. Salmi TT, Collin P, Reunala T, et al. Diagnostic methods beyond conventional histology. Dig Liver Dis. 2010;42:28–32
  5. Hill PG, Holmes GK. Coeliac disease: a biopsy is not always necessary for diagnosis. Aliment Pharmacol Ther. 2008;27:572–577
  6. Salmi TT, Collin P, Järvinen O, et al. Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming celiac disease. Aliment Pharmacol Ther. 2006;24:541–552
  7. Abrams JA, Diamond B, Rotterdam H, et al. Seronegative celiac disease: increased prevalence with lesser degrees of villous atrophy. Dig Dis Sci. 2004;49:546–550
  8. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol. 1999;11:1185–1194
  9. Karell K, Louka AS, Moodie SJ, et al. HLA type in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum Immunol. 2003;64:469–477
  10. Simell S, Hoppu S, Hekkala A, et al. Fate of five celiac disease-associated antibodies during normal diet in genetically at-risk children observed from birth in a natural history study. Am J Gastroenterol. 2007;102:2026–2035

 Funding: This manuscript was partially funded by the Center for Celiac Research, University of Maryland School of Medicine.

 Conflict of Interest: Both authors disclose no conflict of interests related to the content of this manuscript.

 Authorship: Both authors had access to the data and had equal role in writing the manuscript.

PII: S0002-9343(10)00359-1

doi: 10.1016/j.amjmed.2010.02.019

The American Journal of Medicine
Volume 123, Issue 8 , Pages 691-693 , August 2010

Article Tools