The American Journal of Medicine
Volume 123, Issue 8 , Pages 765-768 , August 2010

No Effect of Selenium Supplementation on Serum Glucose Levels in Men with Prostate Cancer

  • Amit M. Algotar, PhD, MBBS

      Affiliations

    • Arizona Cancer Center, College of Medicine, University of Arizona, Tucson
    • ,
  • Mimi Suzanne Stratton, PhD

      Affiliations

    • Arizona Cancer Center, College of Medicine, University of Arizona, Tucson
    • ,
  • Steven P. Stratton, PhD

      Affiliations

    • Arizona Cancer Center, College of Medicine, University of Arizona, Tucson
    • Department of Medicine, College of Medicine, University of Arizona, Tucson
    • Corresponding Author InformationRequests for reprints should be addressed to Steven P. Stratton, PhD, Arizona Cancer Center, University of Arizona, PO Box 245024, 1515 N Campbell Ave, Tucson, AZ 85724
    • ,
  • Chiu-Hsieh Hsu, PhD

      Affiliations

    • Arizona Cancer Center, College of Medicine, University of Arizona, Tucson
    • Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson
    • ,
  • Frederick R. Ahmann, MD

      Affiliations

    • Arizona Cancer Center, College of Medicine, University of Arizona, Tucson
    • Department of Medicine, College of Medicine, University of Arizona, Tucson

References 

  1. Duffield-Lillico AJ, Dalkin BL, Reid ME, et al. Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU Int. 2003;91:608–612
  2. Clark LC, Combs GF, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin (A randomized controlled trial. Nutritional Prevention of Cancer Study Group). JAMA. 1996;276:1957–1963
  3. Clark LC, Dalkin B, Krongrad A, et al. Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. Br J Urol. 1998;81:730–734
  4. Stranges S, Marshall JR, Natarajan R, et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med. 2007;147:217–223
  5. Bleys J, Navas-Acien A, Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality among US adults. Arch Intern Med. 2008;168:404–410
  6. Lippman SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009;301:39–51
  7. Stratton MS, Reid ME, Schwartzberg G, et al. Selenium and inhibition of disease progression in men diagnosed with prostate carcinoma: study design and baseline characteristics of the ‘Watchful Waiting’ Study. Anticancer Drugs. 2003;14:595–600
  8. Bleyer AJ, Hire D, Russell GB, et al. Ethnic variation in the correlation between random serum glucose concentration and glycated haemoglobin. Diabet Med. 2009;26:128–133
  9. Laird NM, Ware JH. Random-effects models for longitudinal data. Biometrics. 1982;38:963–974
  10. Kosiborod M, Inzucchi SE, Goyal A, et al. Relationship between spontaneous and iatrogenic hypoglycemia and mortality in patients hospitalized with acute myocardial infarction. JAMA. 2009;301:1556–1564

 Funding: National Cancer Institute grants CA079080 and CA023074.

 Conflict of Interest: All authors declare that there are no competing interests. No pharmaceutical industry funds were received for this work.

 Authorship: All authors had full access to all of the data in the study and a role in writing the manuscript. All authors take responsibility for the integrity of the data and the accuracy of the data analysis.

PII: S0002-9343(10)00353-0

doi: 10.1016/j.amjmed.2010.02.018

The American Journal of Medicine
Volume 123, Issue 8 , Pages 765-768 , August 2010

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