Venous Compression for Prevention of Postthrombotic Syndrome: A Meta-analysis
Abstract
Purpose
To determine the effectiveness of venous compression stockings or compression bandages on the reduction of postthrombotic syndrome in patients with deep venous thrombosis.
Methods
We attempted to identify all published trials in all languages identified by PubMed through June 2009. Meta-analysis was performed.
Results
Based on 5 randomized trials of patients with deep venous thrombosis comparing treatment with venous compression to controls, mild-to-moderate postthrombotic syndrome occurred in 64 of 296 (22%) treated with venous compression, compared with 106 of 284 (37%) in controls (relative risk=0.52). Severe postthrombotic syndrome occurred in 14 of 296 (5%) treated, compared with 33 of 284 (12%) controls (relative risk=0.38). Any postthrombotic syndrome occurred in 89 of 338 (26%) treated, compared with 150 of 324 (46%) controls (relative risk=0.54).
Conclusion
Venous compression reduced the incidence of postthrombotic syndrome, particularly severe postthrombotic syndrome. Venous compression in patients with deep venous thrombosis would seem to be indicated for this purpose. There was, however, wide variation in the type of stockings used, time interval from diagnosis to application of stockings, and duration of treatment. Further investigation, therefore, is needed.
aDepartment of Internal Medicine, St. Joseph Mercy Oakland, Pontiac, Mich
bDepartments of Internal Medicine and Research and Advanced Studies Program, College of Osteopathic Medicine, Michigan State University, East Lansing
cDepartment of Internal Medicine, St. Mary Mercy, Livonia, Mich
dDepartment of Medicine, University of Calgary, Alberta, Canada
Requests for reprints should be addressed to Paul D. Stein, MD, Department of Internal Medicine, Michigan State University, College of Osteopathic Medicine, MSU Venous Thromboembolism Research Unit, 44405 Woodward Ave., Pontiac, MI 48341-5023
Funding: None.
Conflict of Interest: None of the authors have any financial or other potential conflicts of interest relative to the data in this manuscript.
Authorship: All authors had access to the data and a role in writing the manuscript.
ABSTRACT
