The American Journal of Medicine
Volume 123, Issue 8 , Pages 719-726 , August 2010

Blood Pressure and Outcomes in Very Old Hypertensive Coronary Artery Disease Patients: An INVEST Substudy

  • Scott J. Denardo, MD

      Affiliations

    • Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville
    • Corresponding Author InformationRequests for reprints should be addressed to Scott J. Denardo, MD, Division of Cardiovascular Medicine, University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100277, Gainesville, FL 32610
    • ,
  • Yan Gong, PhD

      Affiliations

    • Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville
    • ,
  • Wilmer W. Nichols, PhD

      Affiliations

    • Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville
    • ,
  • Franz H. Messerli, MD

      Affiliations

    • Division of Cardiology, St Luke's-Roosevelt Hospital Center and Columbia University College of Medicine and Physicians, New York, NY
    • ,
  • Anthony A. Bavry, MD, MPH

      Affiliations

    • Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville
    • ,
  • Rhonda M. Cooper-DeHoff, PharmD

      Affiliations

    • Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville
    • Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville
    • ,
  • Eileen M. Handberg, PhD

      Affiliations

    • Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville
    • ,
  • Annette Champion, MBA

      Affiliations

    • Abbott Laboratory, Abbott Park, Ill
    • ,
  • Carl J. Pepine, MD

      Affiliations

    • Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville

  • Image Result

    Systolic blood pressure (A), diastolic blood pressure (B), and pulse pressure (C) as a function of age (in 10-year increments) and time.

    Systolic blood pressure (A), diastolic blood pressure (B), and pulse pressure (C) as a function of age (in 10-year increments) and time.

  • Image Result

    Primary and secondary outcomes as a function of age (in 10-year increments).

    Primary and secondary outcomes as a function of age (in 10-year increments).

  • Image Result

    Fatal myocardial infarction and stroke as a function of age (in 10-year increments).

    Fatal myocardial infarction and stroke as a function of age (in 10-year increments).

  • Image Result

    Primary and secondary outcomes as a function of age (in 10-year increments) based upon treatment strategy.

    Primary and secondary outcomes as a function of age (in 10-year increments) based upon treatment strategy.

  • Image Result

    Adjusted hazard ratio as a function of age (in 10-year increments), systolic and diastolic blood pressure. Reference systolic and diastolic blood pressure for hazard ratio: 140 and 90 mm Hg, respectiv

    Adjusted hazard ratio as a function of age (in 10-year increments), systolic and diastolic blood pressure. Reference systolic and diastolic blood pressure for hazard ratio: 140 and 90 mm Hg, respectively. Blood pressures are the on-treatment average of all postbaseline recordings. The quadratic terms for both systolic and diastolic blood pressures were statistically significant in all age groups (all P <.001, except for diastolic blood pressure in 60-70-year-olds for whom P=0.006). The adjustment was based upon sex, race, history of myocardial infarction, heart failure, peripheral vascular disease, diabetes, stroke/transient ischemic attack, renal insufficiency, and smoking.

 Funding: Financial support for this research: None. Financial support for original INVEST: University of Florida (Gainesville, Fla); Abbott Laboratories (Abbott Park, Ill).

 Conflict of Interest: Potential conflicts of interest: Dr. Denardo: None; Dr. Gong: None; Dr. Nichols: None; Dr. Messerli: Abbott Laboratories (ad hoc consultant; speaker); Dr. Cooper-DeHoff: Abbott Laboratories (grant); Dr. Handberg: Abbott Laboratories (grant); Ms. Champion: Abbott Laboratories (employee; stock/stock options); Dr. Pepine: Abbott Laboratories (grant; ad hoc consultant).

 Authorship: All authors had access to the data and a role in writing the manuscript.

PII: S0002-9343(10)00343-8

doi: 10.1016/j.amjmed.2010.02.014

The American Journal of Medicine
Volume 123, Issue 8 , Pages 719-726 , August 2010

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