The American Journal of Medicine
Volume 123, Issue 6 , Pages 536-541 , June 2010

Adherence to Pharmacological Thromboprophylaxis Orders in Hospitalized Patients

  • John Fanikos, RPh, MBA

      Affiliations

    • Department of Pharmacy, Brigham and Women's Hospital, Boston, Mass
    • ,
  • Leslie Ann Stevens, BS

      Affiliations

    • Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
    • ,
  • Matthew Labreche

      Affiliations

    • Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
    • ,
  • Gregory Piazza, MD

      Affiliations

    • Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
    • ,
  • Elaine Catapane, MEd, MT (ASCP)

      Affiliations

    • Harvard Clinical Research Institute, Harvard Medical School, Boston, Mass
    • ,
  • Lena Novack, PhD

      Affiliations

    • Harvard Clinical Research Institute, Harvard Medical School, Boston, Mass
    • ,
  • Samuel Z. Goldhaber, MD

      Affiliations

    • Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
    • Corresponding Author InformationRequests for reprints should be addressed to Samuel Z. Goldhaber, MD, Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115

References 

  1. Galson S. The Surgeon General's call to action to prevent deep vein thrombosis and pulmonary embolism. http://www.surgeongeneral.gov/topics/deepvein/Accessed July 16, 2009
  2. Centers for Medicare and Medicaid Services. Medicare and Medicaid move aggressively to encourage greater patient safety in hospitals and reduce never events. http://www.cms.hhs.gov/apps/media/press/release.asp?Counter=3219&intNumPerPage=10&checkDate=&checkKey=&srchType=1&numDays=3500&srchOpt=0&srchData=&keywordType=All&chkNewsType=1%2C+2%2C+3%2C+4%2C+5&intPage=&showAll=&pYear=&year=&desc=&cboOrder=dateAccessed July 16, 2009
  3. The Joint Commission. National consensus standards for prevention and care of venous thromboembolism (VTE). http://www.jointcommission.org/PerformanceMeasurement/PerformanceMeasurement/VTE.htmAccessed July 16, 2009
  4. Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl):381S–453S
  5. Amin A, Stemkowski S, Lin J, Yang G. Thromboprophylaxis rates in US medical centers: success or failure?. J Thromb Haemost. 2007;5:1610–1616
  6. Yu HT, Dylan ML, Lin J, Dubois RW. Hospitals' compliance with prophylaxis guidelines for venous thromboembolism. Am J Health Syst Pharm. 2007;64:69–76
  7. Cohen AT, Tapson VF, Bergmann JF, et al. ; ENDORSE Investigators (Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study). Lancet. 2008;371:387–394
  8. Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009;119:3028–3035
  9. Kucher N, Koo S, Quiroz R, et al. Electronic alerts to prevent venous thromboembolism among hospitalized patients. N Engl J Med. 2005;352:969–977
  10. Casagrande JT, Pike MC. An improved approximate formula for calculating sample sizes for comparing two binomial distributions. Biometrics. 1978;34:483–486
  11. Fleiss JL. Statistical Methods for Rates and Proportions. 2nd edn.. New York: Wiley; 1981;
  12. Hirsh J, O'Donnell M, Eikelboom JW. Beyond unfractionated heparin and warfarin: current and future advances. Circulation. 2007;116:552–560
  13. Le Sage S, McGee M, Emed JD. Knowledge of venous thromboembolism (VTE) prevention among hospitalized patients. J Vasc Nurs. 2008;26:109–117
  14. Osterberg L, Blascheke T. Adherence to medications. N Engl J Med. 2005;353:487–497
  15. Baroletti S, Munz K, Sonis J, et al. Electronic alerts for hospitalized high-VTE risk patients not receiving prophylaxis: a cohort study. J Thromb Thrombolysis. 2008;25:146–150
  16. Piazza G, Rosenbaum EJ, Pendergast W, et al. Physician alerts to prevent symptomatic venous thromboembolism in hospitalized patients. Circulation. 2009;119:2196–2201
  17. Centers for Medicare and Medicaid Services. Federal Register. August 19, 2008. Changes to the Hospital Inpatient Prospective Payment Systems and Fiscal Year 2009 Rates; Payments for Graduate Medical Education in Certain Emergency Situations, Changes to Disclosure of Physician Ownership in Hospitals and Physician Self-Referral Rules; Updates to the Long-Term Care Prospective Payment System; Updates to Certain IPPS-Excluded Hospitals; and Collection of Information Regarding Financial Relationships Between Hospitals; Final Rule. http://www.access.gpo.gov/su_docs/fedreg/a080819c.htmlAccessed July 16, 2009

 Funding: Sanofi-aventis.

 Conflict of Interest: John Fanikos, RPh, MBA serves on the Speakers Bureau for sanofi-aventis and GlaxoSmithKline and has served as a consultant/advisory board participant. Samuel Z. Goldhaber, MD, receives research funds and is a consultant for sanofi-aventis, Eisai, Bristol-Myers Squibb, and Boehringer-Ingelheim. The remaining authors have no conflicts to disclose.

 Authorship: All authors had access to the data and participated in the manuscript preparation.

PII: S0002-9343(10)00066-5

doi: 10.1016/j.amjmed.2009.11.017

The American Journal of Medicine
Volume 123, Issue 6 , Pages 536-541 , June 2010

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