The American Journal of Medicine
Volume 123, Issue 6 , Pages 496-501 , June 2010

Review: Treatment of Gastroesophageal Reflux Disease in the Elderly

References 

  1. Greenwald DA. Aging, the gastrointestinal tract, and risk of acid-related disease. Am J Med. 2004;117:8S–13S
  2. Locke GR, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmstead County, Minnesota. Gastroenterology. 1997;112:1448–1456
  3. Räihä IJ, Impivaara O, Seppälä M, Sourander LB. Prevalence and characteristics of symptomatic gastroesophageal reflux disease in the elderly. J Am Geriatr Soc. 1992;40:1209–1211
  4. Zhu H, Pace F, Sangaletti O, et al. Features of symptomatic gastroesophageal reflux in elderly patients. Scand J Gastroenterol. 1993;28:235–238
  5. Shaker R, Ren J, Zamir Z, et al. Effect of aging, position, and temperature on the threshold volume triggering pharyngeal swallows. Gastroenterology. 1994;107:396–402
  6. Plant RL. Anatomy and physiology of swallowing in adults and geriatrics. Otolaryngol Clin North Am. 1998;31:447–488
  7. Collen MJ, Abdulian JD, Chen YK. Age does not affect basal gastric acid secretion in normal subjects or in patients with acid-peptic disease. Am J Gastroenterol. 1994;89:712–716
  8. Hurwitz A, Brady DA, Schaal SE, et al. Gastric acidity in older adults. JAMA. 1997;278:659–662
  9. Mold JW, Reed LE, Davis AB, et al. Prevalence for gastroesophageal reflux in elderly patients in a primary care setting. Am J Gastroenterol. 1991;86:965–970
  10. Tack J, Vantrappen G. The aging oesophagus. Gut. 1997;41:422–424
  11. Khajanchee YS, Urbach DR, Butler N, et al. Laparoscopic antireflux surgery in the elderly. Surg Endosc. 2002;16:25–30
  12. Patti MG, Goldberg HI, Arcerito M, et al. Hiatal hernia size affects lower esophageal sphincter function, esophageal acid exposure, and the degree of mucosal injury. Am J Surg. 1996;171:182–186
  13. Pilotto A, Franceschi M, Leandro G, et al. Clinical features of reflux esophagitis in older people: a study of 840 consecutive patients. J Am Geriatr Soc. 2006;54:1537–1542
  14. Räihä I, Hietanen E, Sourander L. Symptoms of gastro-oesophageal reflux disease in elderly people. Age Ageing. 1991;20:365–370
  15. Collen MJ, Abdulian JD, Chen YK. Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy. Am J Gastroenterol. 1995;90:1053–1057
  16. Johnson DA, Fennerty MB. Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease. Gastroenterology. 2004;126:660–664
  17. Fass R, Pulliam G, Johnson C, et al. Symptom severity and oesophageal chemosensitivity to acid in older and young patients with gastro-oesophageal reflux. Age Ageing. 2000;29:125–130
  18. Kaltenbach T, Crockett S, Gerson LB. Are lifestyle measures effective in patients with gastroesophageal reflux disease? (An evidence-based approach). Arch Intern Med. 2006;166:965–971
  19. Weberg R, Berstad A. Symptomatic effect of a low-dose antacid regimen in reflux oesophagitis. Scand J Gastroenterol. 1989;24:401–406
  20. Carling L, Cronstedt J, Engqvist A, et al. Sucralfate versus placebo in reflux esophagitis (A double-blind multicenter study). Scand J Gastroenterol. 1988;23:1117–1124
  21. Richter JE. Novel medical therapies for gastroesophageal reflux disease beyond proton-pump inhibitors. Gastroenterol Clin North Am. 2002;31:S111–S116
  22. Richter JE. Gastroesophageal reflux disease in the older patient: presentation, treatment, and complications. Am J Gastroenterol. 2000;95:368–373
  23. Lipsy FJ, Fennerty B, Fagan TC. Clinical review of histamine2 receptor antagonists. Arch Intern Med. 1990;150:745–755
  24. Boustani M, Hall KS, Lane KA, et al. The association between cognition and histamine-2 receptor antagonists in African Americans. J Am Geriatr Soc. 2007;55:1248–1253
  25. James OF, Parry-Billings KS. Comparison of omeprazole and histamine H2-receptor antagonists in the treatment of elderly and young patients with reflux oesophagitis. Age Ageing. 1994;23:121–126
  26. Pilotto A, Leandro G, Franceschi M Ageing and Acid-Related Disease Study Group. Short- and long-term therapy for reflux oesophagitis in the elderly: a multi-centre, placebo-controlled study with pantoprazole. Aliment Pharmacol Ther. 2003;17:1399–1406
  27. Cheer SM, Prakash A, Faulds D, Lamb HM. Pantoprazole: an update of its pharmacological properties and therapeutic use in the management of acid-related disorders. Drugs. 2003;63:101–133
  28. McColl KEL. Effect of proton pump inhibitors on vitamins and iron. Am J Gastroenterol. 2009;104:S5–S9
  29. Juurlink DN, Gomes T, Ko DT, et al. A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ. 2009;180:713–718
  30. Wilde MI, McTavish D. Omeprazole (An update of its pharmacology and therapeutic use in acid-related disorders). Drugs. 1994;48:91–132
  31. Koury SI, Stone CK, La Charité DD. Omeprazole and the development of acute hepatitis. Eur J Emerg Med. 1998;5:467–469
  32. Yip D, Kovac S, Jardine M, et al. Omeprazole-induced interstitial nephritis. J Clin Gastroenterol. 1997;25:450–452
  33. Jose J, Saravu K, Khera K, et al. Acute interstitial nephritis related to lansoprazole administration. J Pak Med Assoc. 2008;58:206–207
  34. Geevasinga N, Coleman PL, Roger SD. Rabeprazole-induced acute interstitial nephritis. Nephrology (Carlton). 2005;10:7–9
  35. Singh P, Indaram A, Greenberg R, et al. Long term omeprazole therapy for reflux esophagitis: follow-up in serum gastrin levels, EC cell hyperplasia and neoplasia. World J Gastroenterol. 2000;6:789–792
  36. Hage E, Hendel L, Gustafsen J, Hendel J. Histopathology of the gastric oxyntic mucosa in two different patient groups during long-term treatment with omeprazole. Eur J Gastroenterol Hepatol. 2003;15:781–789
  37. O'Connell MB, Madden DM, Murray AM, et al. Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. Am J Med. 2005;118:778–781
  38. Yang YX, Lewis JD, Epstein S, Metz DC. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006;296:2947–2953
  39. Laheij RJF, Sturkenboom MCJM, Hassing R-J, et al. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. JAMA. 2004;292:1955–1960
  40. Dial S, Alrasadi K, Manoukian C, et al. Risk of Clostridium difficile diarrhea in hospital in-patients prescribed proton pump inhibitors: cohort and case-control studies. CMAJ. 2004;171:33–38
  41. Fass R, Sifrim D. Management of heartburn not responding to proton pump inhibitors. Gut. 2009;58:295–309
  42. Dodds WJ, Dent J, Hogan WJ, et al. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med. 1982;307:1547–1552
  43. Vela MF, Tutuian R, Katz PO, Castell DO. Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH. Aliment Pharmacol Ther. 2003;17:243–251
  44. Smith PM, Kerr GD, Cockel R, et al. A comparison of omeprazole and ranitidine in the prevention of recurrence of benign esophageal stricture (Restore Investigator Group). Gastroenterology. 1994;107:1312–1318
  45. Sharma P, Falk GW, Sampliner R, et al. Management of nondysplastic Barrett's esophagus: where are we now?. Am J Gastroenterol. 2009;104:805–808
  46. Shaheen NJ, Richter JE. Barrett's oesophagus. Lancet. 2009;373:850–861
  47. Hinder RA, Filipi CJ, Wetscher G, et al. Laparoscopic Nissen fundoplication is an effective treatment for gastroesophageal reflux disease. Ann Surg. 1994;220:472–481
  48. Bammer T, Hinder RA, Klaus A, et al. Safety and long-term outcome of laparoscopic antireflux surgery in patients in their eighties and older. Surg Endosc. 2002;16:40–42

 Funding: There was no outside funding for this manuscript.

 Conflict of Interest: None of the authors has any conflict of interest relevant to this manuscript.

 Authorship: All authors had access to the data and participated in writing this manuscript.

PII: S0002-9343(10)00005-7

doi: 10.1016/j.amjmed.2009.07.036

The American Journal of Medicine
Volume 123, Issue 6 , Pages 496-501 , June 2010

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