The American Journal of Medicine
Volume 123, Issue 4 , Pages 322-328.e2 , April 2010

Long-acting Beta-Agonists with and without Inhaled Corticosteroids and Catastrophic Asthma Events

  • Shelley R. Salpeter, MD, FACP

      Affiliations

    • Stanford University School of Medicine, Stanford, Calif
    • Santa Clara Valley Medical Center, San Jose, Calif
    • Corresponding Author InformationReprint requests should be addressed to Shelley Salpeter, MD, 751 S. Bascom Ave, San Jose, CA 95128
    • ,
  • Andrew J. Wall, MD

      Affiliations

    • Stanford University School of Medicine, Stanford, Calif
    • Santa Clara Valley Medical Center, San Jose, Calif
    • ,
  • Nicholas S. Buckley

      Affiliations

    • California Institute for Technology, Pasadena

  • Image Result

    Flow chart of trials search.

    Flow chart of trials search.

  • Image Result

    Effect of long-acting β-agonists on asthma intubations and deaths. 1. Long-acting β-agonists with variable inhaled corticosteroids compared with placebo. 2. Long-acting β-agonists with concomitant inh

    Effect of long-acting β-agonists on asthma intubations and deaths. 1. Long-acting β-agonists with variable inhaled corticosteroids compared with placebo. 2. Long-acting β-agonists with concomitant inhaled corticosteroids compared with inhaled corticosteroids alone. n=number of participants with at least 1 asthma intubation or death; N=number of participants; SMART=Salmeterol Multi-center Asthma Research Trial; GSK=GlaxoSmithKline; OR = odds ratio; CI=confidence interval.

 Funding: Santa Clara Valley Medical Center, San Jose, Calif.

 Conflict of Interest: None of the authors have any conflicts of interest associated with the work presented in this manuscript. None of the authors have had any relationships with a pharmaceutical company that manufactures a β-agonist or other respiratory medications. Dr Salpeter has provided expert testimony on a litigation case involving a long-acting β-agonist and was paid on an hourly basis.

 Authorship: All authors had access to the data and played a role in writing this manuscript.

PII: S0002-9343(09)01110-3

doi: 10.1016/j.amjmed.2009.07.035

The American Journal of Medicine
Volume 123, Issue 4 , Pages 322-328.e2 , April 2010

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