The American Journal of Medicine
Volume 123, Issue 5 , Pages 454-461 , May 2010

Long-term TNF-α Blockade in Patients with Amyloid A Amyloidosis Complicating Rheumatic Diseases

  • Antonio Fernández-Nebro, MD, PhD

      Affiliations

    • Servicio de Reumatología y Departamento de Medicina de la Facultad de Medicina, Hospital Regional Universitario Carlos Haya, Málaga, Spain
    • Corresponding Author InformationReprint requests should be addressed to Antonio Fernández-Nebro, MD, PhD, Servicio de Reumatología, Hospital Regional Universitario Carlos Haya, Pabellón C: “Hospital Civil,” Plaza del Hospital Civil s/n, 29009, Málaga, Spain
    • ,
  • Alejandro Olivé, MD, PhD

      Affiliations

    • Rheumatology Section, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain
    • ,
  • María Carmen Castro, MD, PhD

      Affiliations

    • Servicio de Reumatología, Hospital Universitario Reina Sofía, Córdoba, Spain
    • ,
  • Angela Herranz Varela, MD

      Affiliations

    • Unidad de Investigación, Fundación Española de Reumatología, Madrid, Spain
    • ,
  • Elena Riera, MD

      Affiliations

    • Rheumatology Section, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain
    • ,
  • Maria V. Irigoyen, MD

      Affiliations

    • Servicio de Reumatología y Departamento de Medicina de la Facultad de Medicina, Hospital Regional Universitario Carlos Haya, Málaga, Spain
    • ,
  • María Jesús García de Yébenes, MD, PhD

      Affiliations

    • Unidad de Investigación, Fundación Española de Reumatología, Madrid, Spain
    • ,
  • Rosario García-Vicuña, MD, PhD

      Affiliations

    • Rheumatology Service, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain

  • Image Result

    Evolution of kidney parameter means in patients with amyloid A amyloidosis treated with anti-tumor necrosis factor drugs. Analysis of repeated-measure analysis of variance (Friedman test was used in t

    Evolution of kidney parameter means in patients with amyloid A amyloidosis treated with anti-tumor necrosis factor drugs. Analysis of repeated-measure analysis of variance (Friedman test was used in the proteinuria) is limited to the first 24 months (the median of follow-up). Abscissa axis shows the estimated marginal means of proteinuria (g/d) (A), serum creatinine (mg/dL) (B), and creatinine clearance (mL/min) (C).

  • Image Result
    Evolution of acute phase reactant means in patients with amyloid A amyloidosis treated with anti-tumor necrosis factor drugs. Analysis of repeated-measure analysis of variance is limited to the first

    Evolution of acute phase reactant means in patients with amyloid A amyloidosis treated with anti-tumor necrosis factor drugs. Analysis of repeated-measure analysis of variance is limited to the first 24 months (median of follow-up). Post hoc test of analysis of variance (Bonferroni-Dunn test) did not demonstrate significant changes between each visit after the third month. Abscissa axes show the estimated marginal means of erythrocyte sedimentation rate (A) and C-reactive protein (B). ESR=erythrocyte sedimentation rate; CRP=C-reactive protein.

 Funding: None. The drugs administered to our patients were supplied by the sanitary service as part of the medical care that they normally received.

 Conflict of Interest: None of the authors have any conflicts of interest associated with the work presented in this manuscript; however, Antonio Fernández-Nebro has earned $1500 or more per year as speaker or consultant (included all companies) for Abbott, Roche, Schering-Plough, and Bristol-Meyer-Squibb companies during the past 3 years, and Rosario García-Vicuña has earned $1500 or more per year as speaker or consultant (included all companies) for Abbott, Roche, Schering-Plough, and Wyeth companies during the past 3 years.

 Authorship: All authors had access to the data and played a role in writing this manuscript. Dr Fernández-Nebro had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study conception and design: Fernández-Nebro, García-Vicuña, Olivé. Acquisition of data: Fernández-Nebro, Herranz, Riera, Castro. Analysis and interpretation of data: Fernández-Nebro, García de Yébenes, García-Vicuña, Olivé.

PII: S0002-9343(09)01100-0

doi: 10.1016/j.amjmed.2009.11.010

The American Journal of Medicine
Volume 123, Issue 5 , Pages 454-461 , May 2010

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