The American Journal of Medicine
Volume 123, Issue 2 , Pages 131-133 , February 2010

Symmetrical Brain Calcifications

  • Ming-Tsung Sun, MD

      Affiliations

    • Department of Internal Medicine, Hualien Armed Forces General Hospital, Hualien, Taiwan
    • Division of Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan
    • ,
  • Sung-Sen Yang, MD, PhD

      Affiliations

    • Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan
    • ,
  • Chun-Jung Juan, MD, PhD

      Affiliations

    • Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan
    • ,
  • Shih-Hua Lin, MD

      Affiliations

    • Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan
    • Corresponding Author InformationRequests for reprints should be addressed to Shih-Hua Lin, MD, Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, No 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan

References 

  1. Illum F, Dupont E. Prevalences of CT-detected calcification in the basal ganglia in idiopathic hypoparathyroidism and pseudohypoparathyroidism. Neuroradiology. 1985;27:32–37
  2. Nakamura Y, Matsumoto T, Tamakoshi A, et al. Prevalence of idiopathic hypoparathyroidism and pseudohypoparathyroidism in Japan. J Epidemiol. 2000;10:29–33
  3. Bastepe M, Fröhlich LF, Hendy GN, et al. Autosomal dominant pseudohypoparathyroidism type Ib is associated with a heterozygous microdeletion that likely disrupts a putative imprinting control element of GNAS. J Clin Invest. 2003;112:1255–1263
  4. Jüppner H, Linglart A, Fröhlich LF, Bastepe M. Autosomal-dominant pseudohypoparathyroidism type Ib is caused by different microdeletions within or upstream of the GNAS locus. Ann NY Acad Sci. 2006;1068:250–255
  5. Lania A, Mantovani G, Spada A. G protein mutations in endocrine diseases. Eur J Endocrinol. 2001;145:543–559
  6. Weinstein LS, Yu S, Warner DR, Liu J. Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting. Endocr Rev. 2001;22:675–705
  7. Kowdley KV, Coull BM, Orwoll ES. Cognitive impairment and intracranial calcification in chronic hypoparathyroidism. Am J Med Sci. 1999;317:273–277
  8. Bushinsky DA, Monk RD. Electrolyte quintet: calcium. Lancet. 1998;352:306–311
  9. Tohme JF, Bilezikian JP. Hypocalcemic emergencies. Endocrinol Metab Clin North Am. 1993;22:363–375

 Michael Bettmann, MD, Section Editor

 Funding: None.

 Conflict of Interest: None.

 Authorship: MTS established the first clinical contact with the patient and provided the clinical data. SSY and CJJ helped with the clinical discussion of the case as well as with the references. SHL conducted most of the bibliographical search and coordination of the discussion and takes responsibility for the paper as a whole.

PII: S0002-9343(09)01072-9

doi: 10.1016/j.amjmed.2009.12.002

The American Journal of Medicine
Volume 123, Issue 2 , Pages 131-133 , February 2010

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