The American Journal of Medicine
Volume 123, Issue 4 , Pages 296-303 , April 2010

Toxic Exanthems in the Adult Population

  • Nicole F. Vélez, MD

      Affiliations

    • Department of Medicine, Brigham and Women's Hospital, Boston, Mass
    • Department of Dermatology, Brigham and Women's Hospital, Boston, Mass
  • ,
  • Arturo P. Saavedra-Lauzon, MD, PhD

      Affiliations

    • Department of Medicine, Brigham and Women's Hospital, Boston, Mass
    • Department of Dermatology, Brigham and Women's Hospital, Boston, Mass
    • Corresponding Author InformationRequests for reprints should be addressed to Arturo P. Saavedra-Lauzon, MD, PhD, Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115

References 

  1. Sereni F, Sereni LP. Exanthematous infectious diseases in pediatrics: curiosities from the old pediatric literature. Pediatr Infect Dis J. 2004;23:350–354
  2. Manders SM. Toxin-mediated streptococcal and staphylococcal disease. J Am Acad Dermatol. 1998;39:383–398
  3. Drage L. Life-threatening rashes: dermatologic signs of four infectious diseases. Mayo Clin Proc. 1999;74:68–72
  4. Habif TP. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 4th edn.. New York: Mosby; 2004;
  5. Ramos-e-Silva M, Pereira AL. Life-threatening eruptions due to infectious agents. Clin Dermatol. 2005;23:148–156
  6. Wolf JE, Rabinowitz LG. Streptococcal toxic shock-like syndrome. Arch Dermatol. 1995;131:73–77
  7. Finkelstein S, Hyland RH. Toxic shock syndrome as the acquired immune deficiency syndrome (AIDS)-defining diagnosis. Chest. 1993;104:950–951
  8. Darenberg J, Söderquist B, Normark BH, Norrby-Teglund A. Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens: implications for therapy of toxic shock syndrome. Clin Infect Dis. 2004;38:836–842
  9. Cone LA, Woodard DR, Byrd RG, et al. A recalcitrant, erythematous, desquamating disorder associated with toxin-producing staphylococci in patients with aids. J Infect Dis. 1992;165:638–643
  10. Cribier B, Peimont Y, Grosshans E. Staphylococcal scalded skin syndrome in adults. J Am Acad Dermatol. 1994;30:319–324
  11. Gemmell CG. Staphylococcal scalded skin syndrome. J Med Microbiol. 1995;43:318–327
  12. Farrell AM, Ross JS, Umaskankar S, Bunker CB. Staphylococcal scalded skin syndrome in an HIV-1 seropositive man. Br J Dermatol. 1995;134:962–965
  13. Brown EJ. The molecular basis of streptococcal toxic shock syndrome. N Engl J Med. 2004;350(20):2093–2094
  14. Darenberg J, Ihendyane N, Sjölin J, et al. Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2003;37:333–340
  15. Masters EJ, Olson GS, Weiner SJ, Paddock CD. Rocky Mountain spotted fever: a clinician's dilemma. Arch Intern Med. 2003;163:769–774
  16. Lacz NL, Schwartz RA, Kapila R. Rocky Mountain spotted fever. J Eur Acad Dermatol Venereol. 2006;20:411–417
  17. National Center for Immunization and Respiratory Disease. Typhoid Fever. http://www.cdc.gov/ncidod/dbmd/diseaseinfo/TyphoidFever_g.htmAccessed September 30, 2008
  18. Hoffner RJ, Slaven E, Perez J. Emergency department presentations of typhoid fever. J Emerg Med. 2000;19:317–320
  19. Bialecki C, Feder HM, Grant-Kels JM. The six classical exanthems: a review and update. J Am Acad Dermatol. 1989;21:891–903
  20. Muñoz J, Alonso D, Vilella A, Naniche D. Measles in travelers: are we aware enough?. J Travel Med. 2008;15:124–125
  21. Centers for Disease Control and Prevention (CDC). Update: Measles—United States, January-July 2008. MMWR Morb Mortal Wkly Rep. 2008;57(33):893–896
  22. Carneiro SCS, Cestari T, Allen SH, Ramos e-Silva M. Viral exanthems in the tropics. Clin Dermatol. 2007;25:212–220
  23. Controlprevention of rubella. evaluation and management of suspected outbreaks, rubella in pregnant women, and surveillance for congenital rubella syndrome. MMWR Recomm Rep. 2001;50(RR-12):1–23
  24. Waza K, Inoue K, Matsumura S. Symptoms associated with parvovirus B19 infection in adults: a pilot study. Intern Med. 2007;46:1975–1978
  25. Ikediobi NI, Tyring SK. Cutaneous manifestations of Epstein-Barr virus infection. Dermatol Clin. 2002;20:283–289
  26. Renn CN, Straff W, Dorfmüller A, et al. Amoxicillin-induced exanthema in young adults with infectious mononucleosis: demonstration of drug-specific lymphocyte reactivity. Br J Dermatol. 2002;147:1166–1170
  27. Jappe U. Amoxicillin-induced exanthema in patients with infectious mononucleosis: allergy or transient immunostimulation?. Allergy. 2007;62:1474–1475
  28. Garman ME, Tyring SK. The cutaneous manifestations of HIV infection. Dermatol Clin. 2002;20:193–208
  29. Zalla MJ, Su WPD, Fransway AF. Dermatologic manifestations of human immunodeficiency virus infection. Mayo Clin Proc. 1992;67:1089–1108
  30. Hulsebosch HJ, Claessen FAP, van Ginkel CJW. Human immunodeficiency virus exanthema. J Am Acad Dermatol. 1990;23:483–486
  31. Kobayashi S, Segawa S, Kawashima M, et al. A case of symptomatic primary HIV infection. J Dermatol. 2005;32:137–142
  32. Mert A, Ozaras R, Tabak F, et al. Fever of unknown origin: a review of 20 patients with Adult-onset Still's disease. Clin Rheumatol. 2003;22:89–93
  33. Yang CC, Lee JY, Liu JF, Ho CL. Adult-onset Still's disease with persistent skin eruption and fatal respiratory failure in a Taiwanese woman. Eur J Dermatol. 2006;16:593–594
  34. Slovis BS, Eyler AE. A 33-year-old man with pharyngitis, transient rash, and multiorgan system failure. Chest. 2007;132:1080–1083
  35. Hong YH, Lee CK. A case of adult onset Still's disease with systemic inflammatory response syndrome complicated by fatal status epilepticus. Rheumatol Int. 2008;28:931–933
  36. Sève P, Stankovic K, Smail A, et al. Adult Kawasaki disease: report of two cases and literature review. Semin Arthritis Rheum. 2005;34:785–792
  37. Karoui K, Servais A, Fadel F. Acute renal failure and febrile rash—infectious or not?. Nephrol Dial Transplant. 2007;22:949–951
  38. Johnson ML, Farmer ER. Graft-versus-host reactions in dermatology. J Am Acad Dermatol. 1998;38:369–396
  39. Whalen JG, Jukic DM, English JC. Rash and pancytopenia as initial manifestations of acute graft-versus-host disease after liver transplantation. J Am Acad Dermatol. 2005;52:908–912
  40. Schmuth M, Vogel W, Weinlich G. Cutaneous lesions as the presenting sign of acute graft-versus-host disease following liver transplantation. Br J Dermatol. 1999;141:901–904
  41. Aractingi S, Chosidow O. Cutaneous graft-versus-host disease. Arch Dermatol. 1998;134:602–612
  42. Häusermann P, Walter RB, Halter J. Cutaneous graft-versus-host disease: a guide for the dermatologist. Dermatology. 2008;216:287–304
  43. Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med. 1994;331:1272–1285
  44. Wolf R, Orion E, Marcos B, Matz H. Life-threatening acute adverse cutaneous drug reactions. Clin Dermatol. 2005;23:171–181
  45. Bastuji-Garin S, Fouchard N, Bertocchi M, et al. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol. 2000;115:149–153
  46. Ghislain PD, Roujeau JC. Treatment of severe drug reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis and hypersensitivity syndrome. Dermatol Online J. 2002;8:5
  47. Roujeau JC. Clinical heterogeneity of drug hypersensitivity. Toxicology. 2005;209:123–129
  48. Bachot N, Roujeau JC. Differential diagnosis of severe cutaneous drug eruptions. Am J Clin Dermatol. 2003;4:561–572
  49. Martel P, Laroche L, Courville P. Cutaneous involvement in patients with angioimmunoblastic lymphadenopathy with dysproteinemia: a clinical, immunohistological, and molecular analysis. Arch Dermatol. 2000;136:881–886
  50. Farasat S, Aksentijevich I, Toro JR. Autoinflammatory diseases: clinical and genetic advances. Arch Dermatol. 2008;144:392–402
  51. Toro JR, Aksentijevich I, Hull K, et al. Tumor necrosis factor receptor-associated periodic syndrome. Arch Dermatol. 2000;136:1487–1494
  52. Kanazawa N, Furukawa F. Autoinflammatory syndromes with a dermatological perspective. J Dermatol. 2007;34:601–618

 Funding: None.

 Conflict of Interest: The authors deny any conflicts of interest.

 Authorship: Both authors had access to the data and played a role in writing this manuscript.

PII: S0002-9343(09)01066-3

doi: 10.1016/j.amjmed.2009.09.029

The American Journal of Medicine
Volume 123, Issue 4 , Pages 296-303 , April 2010