The American Journal of Medicine
Volume 123, Issue 4 , Pages 304-311 , April 2010

Does Chronic Microaspiration Cause Idiopathic Pulmonary Fibrosis?

  • Joyce S. Lee, MD

      Affiliations

    • Department of Medicine, University of California San Francisco
    • Corresponding Author InformationRequests for reprints should be addressed to Joyce Lee, MD, Department of Medicine, University of California, 505 Parnassus Avenue, Box 0111, San Francisco, CA 94143
    • ,
  • Harold R. Collard, MD

      Affiliations

    • Department of Medicine, University of California San Francisco
    • ,
  • Ganesh Raghu, MD

      Affiliations

    • Department of Medicine, University of Washington, Seattle
    • ,
  • Matthew P. Sweet, MD, MS

      Affiliations

    • Department of Surgery, University of California San Francisco
    • ,
  • Steven R. Hays, MD

      Affiliations

    • Department of Medicine, University of California San Francisco
    • ,
  • Guilherme M. Campos, MD, FACS

      Affiliations

    • Department of Surgery, University of California San Francisco
    • ,
  • Jeffrey A. Golden, MD

      Affiliations

    • Department of Medicine, University of California San Francisco
    • ,
  • Talmadge E. King Jr., MD

      Affiliations

    • Department of Medicine, University of California San Francisco

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 Funding: NHLBI HL086516.

 Conflict of Interest: Dr. Lee has no conflicts of interest to disclose. Dr. Collard has provided consulting services to Actelion, Amira, InterMune, Gilead Science, Genzyme, CV Therapeutics, Nektar Therapeutics, and Roche, has served on an advisory committee for InterMune, and speaks regularly about idiopathic pulmonary fibrosis. Dr. Raghu has given lectures on the diagnosis and management of interstitial lung diseases and has discussed the potential role of chronic silent microaspiration in the pathogenesis of idiopathic pulmonary fibrosis. Dr. Sweet has no conflicts of interest to disclose. Dr. Hays has no conflicts of interest to disclose. Dr. Campos has no conflicts of interest to disclose. Dr. Golden has no conflicts of interest to disclose. Dr. King has given lectures on the diagnosis and management of interstitial lung diseases and has discussed the recent papers that have discussed the potential role of chronic silent microaspiration in the pathogenesis of idiopathic pulmonary fibrosis and as a potential cause of the acute respiratory decompensation manifested by some patients with idiopathic pulmonary fibrosis. In 2007, Dr. King provided expert testimony that a patient's diffuse parenchymal lung disease (lung fibrosis) was, more likely than not, caused by chronic aspiration.

 Authorship: This manuscript represents original work, and all authors meet the criteria for authorship.

PII: S0002-9343(09)01061-4

doi: 10.1016/j.amjmed.2009.07.033

The American Journal of Medicine
Volume 123, Issue 4 , Pages 304-311 , April 2010

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