The American Journal of Medicine
Volume 123, Issue 3 , Pages 245-249 , March 2010

Orthostatic Syndromes Differ in Syncope Frequency

  • Ajitesh Ojha

      Affiliations

    • The Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Cleveland, Ohio
    • ,
  • Kevin McNeeley

      Affiliations

    • The Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Cleveland, Ohio
    • ,
  • Elizabeth Heller

      Affiliations

    • The Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Cleveland, Ohio
    • ,
  • Amer Alshekhlee, MD

      Affiliations

    • The Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Cleveland, Ohio
    • ,
  • Gisela Chelimsky, MD

      Affiliations

    • Division of Pediatric Gastroenterology, Rainbow Babies and Children's Hospital, Cleveland, Ohio
    • ,
  • Thomas C. Chelimsky, MD

      Affiliations

    • The Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Cleveland, Ohio
    • Corresponding Author InformationRequests for reprints should be addressed to Thomas Chelimsky, MD, Neurologic Institute, University Hospitals Case Medical Center, 11100 Euclid Ave., Cleveland, OH 44106

References 

  1. Sandroni P, Opfer-Gehrking TL, McPhee BR, Low PA. Postural tachycardia syndrome: clinical features and follow-up study. Mayo Clin Proc. 1999;74:1106–1110
  2. Freeman R. A treatment for neurally mediated syncope? ((Don't) hold your breath). Ann Neurol. 2008;63:265–267
  3. Colman N, Nahm K, Ganzeboom KS, et al. Epidemiology of reflex syncope. Clin Auton Res. 2004;14(Suppl 1):9–17
  4. Schondorf R, Low P. Idiopathic postural orthostatic tachycardia syndrome: an attenuated form of acute pandysautonomia?. Neurology. 1993;43:132–136
  5. Ingall TJ, McLeod JG, O'Brien PC. The effect of ageing on autonomic nervous system function. Aust N Z J Med. 1990;20:570–577
  6. Low PA, Caskey PE, Tuck RR, et al. Quantitative sudomotor axon reflex in normal and neuropathic subjects. Ann Neurol. 1983;14:573–580
  7. Fouad FM, Sitthisook S, Vanerio G, et al. Sensitivity and specificity of the tilt table test in young patients with unexplained syncope. Pacing Clin Electrophysiol. 1993;16(Part I):394–400
  8. Fitzpatrick A, Theodorakis P, Vardas P, et al. The incidence of malignant vasovagal syndrome in patients with recurrent syncope. Eur Heart J. 1991;12:389–394
  9. Hainsworth R. Pathophysiology of syncope. (2004) Clin Auton Res. 2004;14(Suppl 1):18–24
  10. Low PA, Novak V, et al. Cerebrovascular regulation in the Postural Orthostatic Tachycardia syndrome. Am J Med Sci. 1999;317:124–133
  11. Stewart JM, Taneja I, Medow MS. Reduced central blood volume and cardiac output and increased vascular resistance during static handgrip exercise in postural tachycardia syndrome. Am J Physiol Heart Circ Physiol. 2007;293:H1908–H1917
  12. Rowell LB. Human Cardiovascular Control. New York: Oxford University Press; 1993;
  13. Pavy-Le Traon A, Hughson RL, Thalamas C, et al. Cerebral autoregulation is preserved in multiple system atrophy: a transcranial Doppler study. Mov Disord. 2006;21:2122–2126
  14. Arbogast S, Alshekhlee A, Hussain Z, et al. Hypotension unawareness in profound orthostatic hypotension. Am J Med. 2009;122:574–580

 Funding: Ajitesh Ojha received a T35 NIH grant for the project. No other funding was received.

 Conflict of Interest: None of the authors have conflicts of interest of financial disclosures to make.

 Authorship: All authors had full access to the data in the study and take responsibility for the integrity of the data and the accuracy of the analysis. All authors had a role in the writing of the manuscript.

PII: S0002-9343(09)00948-6

doi: 10.1016/j.amjmed.2009.09.018

The American Journal of Medicine
Volume 123, Issue 3 , Pages 245-249 , March 2010

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