The American Journal of Medicine
Volume 123, Issue 2 , Pages 134-140 , February 2010

Warfarin Use and Outcomes in Patients with Atrial Fibrillation Complicating Acute Coronary Syndromes

  • Renato D. Lopes, MD, PhD

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • Corresponding Author InformationReprint requests should be addressed to Renato D. Lopes, MD, PhD, Duke University Medical Center Box 3850, Durham, NC 27710
    • ,
  • Aijing Starr

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • ,
  • Carl F. Pieper, DPH

      Affiliations

    • Department of Biostatistics and Bioinformatics, School of Medicine, Duke University, Durham, NC
    • ,
  • Sana M. Al-Khatib, MD, MHS

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • ,
  • L. Kristin Newby, MD, MHS

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • ,
  • Rajendra H. Mehta, MD, MS

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • ,
  • Frans Van de Werf, MD, PhD

      Affiliations

    • Department of Cardiology, University Hospital Gasthuisberg and Leuven Coordinating Center, Leuven, Belgium
    • ,
  • Kenneth W. Mahaffey, MD

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • ,
  • Paul W. Armstrong, MD

      Affiliations

    • Department of Medicine, Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
    • ,
  • Robert A. Harrington, MD

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    • ,
  • Harvey D. White, DSc

      Affiliations

    • Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand
    • ,
  • Lars Wallentin, MD

      Affiliations

    • Uppsala Clinical Research Center, Uppsala, Sweden
    • ,
  • Christopher B. Granger, MD

      Affiliations

    • Duke Clinical Research Institute, Duke University Medical Center, Durham, NC

  • Image Result

    Antithrombotic use according to CHADS2 score. CHADS2=Congestive heart failure, Hypertension, Age>75 years, Diabetes, Prior Stroke/transient ischemic attack.

    Antithrombotic use according to CHADS2 score. CHADS2=Congestive heart failure, Hypertension, Age>75 years, Diabetes, Prior Stroke/transient ischemic attack.

  • Image Result

    Antithrombotic use according to bleeding risk. CHADS2=Congestive heart failure, Hypertension, Age>75 years, Diabetes, Prior Stroke/transient ischemic attack.

    Antithrombotic use according to bleeding risk. CHADS2=Congestive heart failure, Hypertension, Age>75 years, Diabetes, Prior Stroke/transient ischemic attack.

  • Image Result

    Medication given at discharge based on prior stroke.

    Medication given at discharge based on prior stroke.

  • Image Result

    Adjusted 6-month death or myocardial infarction curves according to warfarin use at discharge. MI=myocardial infarction.

    Adjusted 6-month death or myocardial infarction curves according to warfarin use at discharge. MI=myocardial infarction.

 Funding: The Duke Clinical Research Institute.

 Conflict of Interest: The authors state that they have no conflict of interest regarding the content of the article.

 Authorship: All authors had access to the data and played a role in writing this manuscript.

PII: S0002-9343(09)00876-6

doi: 10.1016/j.amjmed.2009.09.015

The American Journal of Medicine
Volume 123, Issue 2 , Pages 134-140 , February 2010

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