The American Journal of Medicine
Volume 123, Issue 3 , Pages 250-258 , March 2010

Long-term Effect of Chronic Oral Anticoagulation with Warfarin after Acute Myocardial Infarction

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    Study inclusion and exclusion process. OAC=oral anticoagulation.

    Study inclusion and exclusion process. OAC=oral anticoagulation.

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    Forester plot of effect of long-term oral anticoagulation on mortality (point estimate proportional to number of events, odds ratio <1 indicates benefit for oral anticoagulation). OAC=oral anticoagula

    Forester plot of effect of long-term oral anticoagulation on mortality (point estimate proportional to number of events, odds ratio <1 indicates benefit for oral anticoagulation). OAC=oral anticoagulation; ATACS=Antithrombotic Therapy in Acute Coronary Syndromes Study; WARIS=Warfarin Aspirin Re-infarction Study; AFTER=Aspirin/Anticoagulants Following Thrombolysis with Eminase in Recurrent infarction study; CARS=Coumadin Aspirin Reinfarction Study; ASPECT=Aspirin and Coumadin after Acute Coronary Syndromes study; CHAMP=Combination Hemotherapy and Mortality Prevention study; APRICOT=Antithrombotics in the Prevention of Reocclusion In Coronary Thrombolysis; LoWASA=Effect of fixed low-dose warfarin added to aspirin in the long term after acute myocardial infarction study.

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    Forester plot of effect of long-term oral anticoagulation on nonfatal stroke (point estimate proportional to number of events, odds ratio <1 indicates benefit for oral anticoagulation). OAC=oral antic

    Forester plot of effect of long-term oral anticoagulation on nonfatal stroke (point estimate proportional to number of events, odds ratio <1 indicates benefit for oral anticoagulation). OAC=oral anticoagulation; WARIS=Warfarin Aspirin Re-infarction Study; CARS=Coumadin Aspirin Reinfarction Study; ASPECT=Aspirin and Coumadin after Acute Coronary Syndromes study; CHAMP=Combination Hemotherapy and Mortality Prevention study; LoWASA=Effect of fixed low-dose warfarin added to aspirin in the long term after acute myocardial infarction study.

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    Forester plot of effect of long-term oral anticoagulation on nonfatal major bleeding (point estimate proportional to number of events, odds ratio >1 indicates excess with oral anticoagulation). OAC=or

    Forester plot of effect of long-term oral anticoagulation on nonfatal major bleeding (point estimate proportional to number of events, odds ratio >1 indicates excess with oral anticoagulation). OAC=oral anticoagulation; WARIS=Warfarin Aspirin Re-infarction Study; ATACS=Antithrombotic Therapy in Acute Coronary Syndromes Study; CARS=Coumadin Aspirin Reinfarction Study; ASPECT=Aspirin and Coumadin after Acute Coronary Syndromes study; CHAMP=Combination Hemotherapy and Mortality Prevention study; APRICOT=Antithrombotics in the Prevention of Reocclusion In Coronary Thrombolysis; LoWASA=Effect of fixed low-dose warfarin added to aspirin in the long term after acute myocardial infarction study.

 Funding: There were no funding sources for this manuscript.

 Conflict of Interest: All authors state that they have no conflict of interest to disclose.

 Authorship: All authors had complete access to the data and the analytical process. All authors contributed significantly to data collection, analysis, and manuscript review, and participated meaningfully in manuscript writing and editing.

PII: S0002-9343(09)00818-3

doi: 10.1016/j.amjmed.2009.08.016

The American Journal of Medicine
Volume 123, Issue 3 , Pages 250-258 , March 2010