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The American Journal of Medicine
Volume 123, Issue 3
, Pages 267-274
, March 2010
Higher Incidence of Mild Cognitive Impairment in Familial Hypercholesterolemia
References
- . Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway. Brain. 2006;129:2823–2839
- Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56:303–308
- . Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun. 1984;120:885–890
- . The role of cerebral amyloid beta accumulation in common forms of Alzheimer disease. J Clin Invest. 2005;115:1121–1129
- Cholesterol, oxidative stress, and Alzheimer's disease: expanding the horizons of pathogenesis. Free Radic Biol Med. 2002;33:173–181
- Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis. 2000;7:321–331
- A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2001;8:890–899
- Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci U S A. 1998;95:6460–6464
- . Link between heart disease, cholesterol, and Alzheimer's disease: a review. Microsc Res Tech. 2000;50:287–290
- Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology. 2003;61:199–205
- . Cholesterol as a risk factor for Alzheimer's disease—epidemiological evidence. Acta Neurol Scand Suppl. 2006;185:50–57
- Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men (The Honolulu-Asia aging study). Arterioscler Thromb Vasc Biol. 2000;20:2255–2260
- Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology. 1998;17:14–20
- Midlife cardiovascular risk factors and risk of dementia in late life. Neurology. 2005;64:277–281
- Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann Intern Med. 2002;137:149–155
- Statins, incident Alzheimer disease, change in cognitive function, and neuropathology. Neurology. 2008;70(19 Pt 2):1795–1802Epub 2008 Jan 16
- . Aging and total cholesterol levels: cohort, period, and survivorship effects. Am J Epidemiol. 1992;136:23–34
- Clearance of amyloid beta-peptide from brain: transport or metabolism?. Nat Med. 2000;6:718
- . Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia. Atherosclerosis. 2004;173:55–68
- The relationship of molecular genetic to clinical diagnosis of familial hypercholesterolemia in a Danish population. Atherosclerosis. 2005;180:155–160
- The use of Achilles tendon sonography to distinguish familial hypercholesterolemia from other genetic dyslipidemias. Arterioscler Thromb Vasc Biol. 2005;25:2203–2208
- . Familial hypercholesterolemia in Spain: case-finding program, clinical and genetic aspects. Semin Vasc Med. 2004;4:67–74
- The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 1984;39:27–38
- . Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967;6:278–296
- . Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
- . Apolipoprotein E genotyping by one-stage PCR. Lancet. 1991;337:1158–1159
- . A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. New York: Oxford University Press; 1998;
- Mild cognitive impairment. Lancet. 2006;367:1262–1270
- Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure (Report of the MCI Working Group of the European Consortium on Alzheimer's Disease). J Neurol Neurosurg Psychiatry. 2006;77:714–718
- . Alzheimer's disease and cholesterol: the fat connection. Neurochem Res. 2007;32:739–750
- Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study. Neurology. 2007;68:751–756
- . Twenty-six-year change in total cholesterol levels and incident dementia: the Honolulu-Asia Aging Study. Arch Neurol. 2007;64:103–107
- The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort. Arch Neurol. 2000;57:808–813
- Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice. Neurobiol Aging. 2006;27:1632–1643
Funding: National Institute on Aging (US) AG-022103, AG-10483; Alzheimer's Association Zenith award; the Spanish Ministry of Health (RT/C03-01 and RT/G03-181); the Familial Hypercolesterolemia Foundation of Spain and the Fundació Privada Catalana de Nutrició i Lípids, Barcelona, Spain.
Conflict of Interest: None of the authors have any conflicts of interest associated with the work presented in this manuscript.
Authorship: All authors had access to the data and played a role in writing this manuscript.
PII: S0002-9343(09)00817-1
doi: 10.1016/j.amjmed.2009.08.015
© 2010 Elsevier Inc. All rights reserved.
« Previous
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The American Journal of Medicine
Volume 123, Issue 3
, Pages 267-274
, March 2010

