The American Journal of Medicine
Volume 122, Issue 12 , Pages 1122-1127 , December 2009

Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes

  • Nader Botros, MD, MPH

      Affiliations

    • Division of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Conn
    • ,
  • John Concato, MD

      Affiliations

    • Division of General Internal Medicine, Yale University School of Medicine, New Haven, Conn
    • Clinical Epidemiology Research Center (CERC), Veterans Affairs Connecticut Healthcare System, West Haven
    • ,
  • Vahid Mohsenin, MD

      Affiliations

    • Division of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Conn
    • ,
  • Bernardo Selim, MD

      Affiliations

    • Division of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Conn
    • ,
  • Kervin Doctor, MD

      Affiliations

    • Clinical Epidemiology Research Center (CERC), Veterans Affairs Connecticut Healthcare System, West Haven
    • ,
  • Henry Klar Yaggi, MD, MPH

      Affiliations

    • Division of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, Conn
    • Clinical Epidemiology Research Center (CERC), Veterans Affairs Connecticut Healthcare System, West Haven
    • Corresponding Author InformationRequests for reprints should be addressed to Henry Klar Yaggi, MD, MPH, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar St., TAC 441s, P.O. Box 208057, New Haven, CT 06520

  • Image Result

    Kaplan-Meier curves for the association of sleep apnea and diabetes. Sleep apnea is defined as apnea-hypopnea index ≥8.

    Kaplan-Meier curves for the association of sleep apnea and diabetes. Sleep apnea is defined as apnea-hypopnea index ≥8.

  • Image Result

    Kaplan-Meier curves examining the impact of regular continuous positive airway pressure on the risk of incident diabetes among patients in the upper 2 quartiles of apnea-hypopnea index severity (quart

    Kaplan-Meier curves examining the impact of regular continuous positive airway pressure on the risk of incident diabetes among patients in the upper 2 quartiles of apnea-hypopnea index severity (quartiles 3 and 4).

 Funding: VA Health Services Research and Development/Clinical Science, Career Development Awards to Dr. Yaggi. National Research Service Award Institutional Research Training Grant (5T32HL07778) to Dr. Botros.

 Conflict of Interest: The authors have no relevant conflicts of interest to disclose.

 Authorship: All authors had access to the data and a role in writing the manuscript.

PII: S0002-9343(09)00679-2

doi: 10.1016/j.amjmed.2009.04.026

The American Journal of Medicine
Volume 122, Issue 12 , Pages 1122-1127 , December 2009

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