A_1c Control in a Primary Care Setting: Self-titrating an Insulin Analog Pre-mix (INITIATEplus Trial)

 Funding: This clinical study was supported by Novo Nordisk Inc., Princeton, NJ.

 Conflict of Interest: The following disclosures address potential conflicts of interest by the authors for the manuscript: David S. Oyer is on the speaker bureau and advisory board for Novo Nordisk Inc., and on the speaker's bureaus for Amylin, Lilly, Merck, Sanofi-Aventis, and Novartis. Mark D. Shepherd is affiliated with the sponsoring organization, Novo Nordisk Inc. as a consultant, national speaker, researcher, recipient of grant support, and a shareholder in the company. Franklin C. Coulter is on the speaker bureau for Novo Nordisk Inc. for Novolog® Mix 70/30 and for Levemir®. He also is on the advisory board for Novolog® Mix 70/30. Anuj Bhargava is on the speaker's bureaus for Novo Nordisk Inc., Sanofi Aventis, Pfizer, Amylin Pharmaceuticals, Abbott Laboratories, Medtronic and Takeda Pharmaceuticals. He has been or is involved in research studies with Novo Nordisk Inc., Pfizer, Amylin Pharmaceuticals, Lilly, Sanofi Aventis and Merck. Jason Brett and Pei-Ling Chu are employees of Novo Nordisk Inc. Bruce S. Trippe has been on the speaker's bureaus for Astra Zenica, Glaxo Smith Kline, Novartis, Merck, Schering Plough, Sanofi Aventis, Novo Nordisk Inc., and Abbott; he has received grant support from Novo Nordisk Inc. for clinical research.

 Authorship: The work submitted in this manuscript is original and all authors meet the criteria for authorship, including access to the data, a role in performing the research, writing the manuscript, and acceptance of responsibility for the scientific content of the manuscript.

PII: S0002-9343(09)00667-6

doi: 10.1016/j.amjmed.2008.12.026

© 2009 Elsevier Inc. All rights reserved.