The American Journal of Medicine
Volume 122, Issue 10 , Pages 939-946.e9 , October 2009

Side Effects of Phytoestrogens: A Meta-analysis of Randomized Trials

  • Clemens B. Tempfer, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Medical University Vienna, Austria
    • Corresponding Author InformationRequests for reprints should be addressed to Clemens Tempfer, MD, Department of Obstetrics & Gynecology; Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna/Austria
    • ,
  • Georg Froese, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Medical University Vienna, Austria
    • ,
  • Georg Heinze, PhD

      Affiliations

    • Department of Medical Statistics, Medical University Vienna, Austria
    • ,
  • Eva-Katrin Bentz, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Medical University Vienna, Austria
    • ,
  • Lukas A. Hefler, MD

      Affiliations

    • Department of Obstetrics and Gynecology, Medical University Vienna, Austria
    • ,
  • Johannes C. Huber, MD, PhD

      Affiliations

    • Department of Obstetrics and Gynecology, Medical University Vienna, Austria

  • Image Result

    Forest plot showing incidence ratios and 95% confidence intervals of side effects in 92 randomized trials comparing phytoestrogens and placebo/no treatment. Phyto=phytoestrogens.

    Forest plot showing incidence ratios and 95% confidence intervals of side effects in 92 randomized trials comparing phytoestrogens and placebo/no treatment. Phyto=phytoestrogens.

  • Image Result

    Funnel plot showing logarithmized incidence ratios of side effects. IRR=incidence rate ratio; SE=standard error.

    Funnel plot showing logarithmized incidence ratios of side effects. IRR=incidence rate ratio; SE=standard error.

  • Image Result

    Forest plot of incidence ratios of side effects according to different study characteristics. IRR=incidence rate ratio; US=United States of America; EU=European Union.

    Forest plot of incidence ratios of side effects according to different study characteristics. IRR=incidence rate ratio; US=United States of America; EU=European Union.

 Funding: None.

 Conflict of Interest: Authors CBT and JCH received lecture fees by Apomedica Inc. All other authors report no conflict of interest.

 Authorship: All authors had access to the data and a role in writing the manuscript.

PII: S0002-9343(09)00542-7

doi: 10.1016/j.amjmed.2009.04.018

The American Journal of Medicine
Volume 122, Issue 10 , Pages 939-946.e9 , October 2009

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