The American Journal of Medicine
Volume 122, Issue 10 , Pages 947-954 , October 2009

Inflammation and Thrombosis Biomarkers and Incident Frailty in Postmenopausal Women

  • Alexander P. Reiner, MD

      Affiliations

    • Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Wash
    • Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Wash
    • Corresponding Author InformationReprint requests should be addressed to Alexander P. Reiner, MD, Department of Epidemiology, Box 357236, University of Washington, Seattle, WA 98195
  • ,
  • Aaron K. Aragaki, MS

      Affiliations

    • Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Wash
  • ,
  • Shelly L. Gray, PharmD, MS

      Affiliations

    • Geriatric Pharmacy Program, School of Pharmacy, University of Washington, Seattle, Wash
  • ,
  • Jean Wactawski-Wende, PhD

      Affiliations

    • Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY
  • ,
  • Jane A. Cauley, DrPH

      Affiliations

    • Department of Epidemiology, University of Pittsburgh, Pittsburgh, Penn
  • ,
  • Barbara B. Cochrane, PhD

      Affiliations

    • Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Wash
    • School of Nursing, University of Washington, Seattle, Wash
  • ,
  • Charles L. Kooperberg, PhD

      Affiliations

    • Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Wash
    • Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, Wash
  • ,
  • Nancy F. Woods, PhD

      Affiliations

    • School of Nursing, University of Washington, Seattle, Wash
  • ,
  • Andrea Z. LaCroix, PhD

      Affiliations

    • Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Wash
    • Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Wash

References 

  1. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol Med Sci. 2001;56A:M146–M156
  2. Woods NF, LaCroix AZ, Gray SL, et al. Frailty: emergence and consequences in women ages 65 and older in The Women's Health Initiative Observational Study. J Am Geriatr Soc. 2005;53:1321–1330
  3. Walston J, Hadley EC, Ferrucci L, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54:991–1001
  4. Cohen HJ, Harris T, Pieper CF. Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly. Am J Med. 2003;114:180–187
  5. Walston J, McBurnie MA, Newman A, et al. Cardiovascular Health Study Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002;162:2333–2341
  6. Ferrucci L, Harris TB, Guralnik JM, et al. Serum IL-6 and the development of disability in older persons. J Am Geriatr Soc. 1999;47:639–646
  7. Ferrucci L, Penninx BW, Volpato S, et al. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc. 2002;50:1947–1954
  8. Penninx BW, Kritchevsky SB, Newman AB, et al. Inflammatory markers and incident mobility limitation in the elderly. J Am Geriatr Soc. 2004;52:1105–1113
  9. Leng SX, Xue QL, Tian J, et al. Inflammation and frailty in older women. J Am Geriatr Soc. 2007;55:864–871
  10. De Fanis U, Wang GC, Fedarko NS, Walston JD, Casolaro V, Leng SX. T-lymphocytes expressing CC chemokine receptor-5 are increased in frail older adults. J Am Geriatr Soc. 2008;56:904–908
  11. Walston J, Fedarko N, Yang H, et al. The physical and biological characterization of a frail mouse model. J Gerontol A Biol Sci Med Sci. 2008;63:391–398
  12. Folsom AR, Boland LL, Cushman M, et al. Frailty and risk of venous thromboembolism in older adults. J Gerontol A Biol Sci Med Sci. 2007;62:79–82
  13. Barzilay JI, Blaum C, Moore T, et al. Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study. Arch Intern Med. 2007;167:635–641
  14. Langer RD, White E, Lewis CE, et al. The Women's Health Initiative Observational Study: baseline characteristics of participants and reliability of baseline measures. Ann Epidemiol. 2003;13(9 suppl):S107–S121
  15. Women's Health Initiative Study Group. Design of the Women's Health Initiative Clinical Trial and Observational Study. Control Clin Trials. 1998;19:61–109
  16. Hays RD, Sherbourne CD, Mazel RM. The RAND 36-Item Health Survey 1.0. Health Econ. 1993;2:217–227
  17. Tuunainen A, Langer RD, Klauber MR, Kripke DF. Short version of the CES-D (Burnam screen) for depression in reference to the structured psychiatric interview. Psychiatry Res. 2001;103:261–270
  18. Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385–401
  19. Mari D, Coppola R, Provenzano R. Hemostasis factors and aging. Exp Gerontol. 2008;43:66–73
  20. Rumley A, Emberson JR, Wannamethee SG, et al. Effects of older age on fibrin D-dimer, C-reactive protein, and other hemostatic and inflammatory variables in men aged 60-79 years. J Thromb Haemost. 2006;4:982–987
  21. Cushman M, Folsom AR, Wang L, et al. Fibrin fragment D-dimer and the risk of future venous thrombosis. Blood. 2003;101:1243–1248
  22. Lowe GD, Danesh J, Lewington S, et al. Tissue plasminogen activator antigen and coronary heart disease (Prospective study and meta-analysis). Eur Heart J. 2004;25:252–259
  23. Danesh J, Whincup P, Walker M, et al. Fibrin D-dimer and coronary heart disease: prospective study and meta-analysis. Circulation. 2001;103:2323–2327
  24. Newman AB, Gottdiener JS, Mcburnie MA, et al. Cardiovascular Health Study Research Group Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Sci Med Sci. 2001;56:M158–M166
  25. Thrall G, Lane D, Carroll D, Lip GY. A systematic review of the effects of acute psychological stress and physical activity on haemorheology, coagulation, fibrinolysis and platelet reactivity: implications for the pathogenesis of acute coronary syndromes. Thromb Res. 2007;120:819–847
  26. von Känel R, Dimsdale JE, Mills PJ, et al. Effect of Alzheimer caregiving stress and age on frailty markers interleukin-6, C-reactive protein, and D-dimer. J Gerontol A Biol Sci Med Sci. 2006;61:963–969
  27. Mausbach BT, von Känel R, Aschbacher K, et al. Spousal caregivers of patients with Alzheimer's disease show longitudinal increases in plasma level of tissue-type plasminogen activator antigen. Psychosom Med. 2007;69:816–822
  28. Matys T, Pawlak R, Matys E, et al. Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior. Proc Natl Acad Sci U S A. 2004;101:16345–16350
  29. McEwen BS. Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol. 2008;583:174–185

 Funding: The Women's Health Initiative program is funded by the National Heart, Lung, and Blood Institute, US Department of Health and Human Services. A full listing of Women's Health Initiative investigators can be found at http://www.whiscience.org/publications/WHI_investigators_shortlist.pdf. This article was supported by grant R01 AG025441 to Dr LaCroix from the National Institute of Aging.

 Conflict of Interest: None of the authors have any conflicts of interest associated with the work presented in this manuscript.

 Authorship: All authors had access to the data and played a role in writing this manuscript.

PII: S0002-9343(09)00539-7

doi: 10.1016/j.amjmed.2009.04.016

The American Journal of Medicine
Volume 122, Issue 10 , Pages 947-954 , October 2009