The American Journal of Medicine
Volume 122, Issue 11 , Pages 1056-1060 , November 2009

Adequacy of Vitamin D Replacement in Severe Deficiency Is Dependent on Body Mass Index

  • Paul Lee, MBBS (Hons)

      Affiliations

    • Department of Endocrinology, St Vincent's Hospital, Sydney, New South Wales, Australia
    • Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Concord, New South Wales, Australia
    • University of New South Wales, Sydney, Australia
    • Corresponding Author InformationRequests for reprints should be addressed to Paul Lee, MBBS (Hons), Department of Endocrinology, St Vincent's Hospital, 384 Victoria Street, Sydney, New South Wales, Australia 2010
    • ,
  • Jerry R. Greenfield, MBBS, PhD

      Affiliations

    • Department of Endocrinology, St Vincent's Hospital, Sydney, New South Wales, Australia
    • University of New South Wales, Sydney, Australia
    • ,
  • Markus J. Seibel, MBBS, PhD

      Affiliations

    • Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Concord, New South Wales, Australia
    • Bone Research Program, ANZAC Research Institute, University of Sydney, New South Wales, Australia
    • ,
  • John A. Eisman, MBBS, PhD

      Affiliations

    • Department of Endocrinology, St Vincent's Hospital, Sydney, New South Wales, Australia
    • University of New South Wales, Sydney, Australia
    • Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    • ,
  • Jacqueline R. Center, MBBS, PhD

      Affiliations

    • Department of Endocrinology, St Vincent's Hospital, Sydney, New South Wales, Australia
    • University of New South Wales, Sydney, Australia
    • Bone and Mineral Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia

References 

  1. Bell NH, Epstein S, Greene A, et al. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest. 1985;76:370–373
  2. Arunabh S, Pollack S, Yeh J, Aloia JF. 2003 Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab. 2003;88:157–161
  3. Worstman J, Matsuoka LY, Chen TC, et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72:690–693
  4. Martins D, Wolf M, Pan D, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007;167:1159–1165
  5. Barger-Lux MJ, Heaney RP, Dowell S, et al. Vitamin D and its major metabolites: serum levels after graded oral dosing in healthy men. Osteoporos Int. 1998;8:222–230
  6. Rajakumar K, Fernstrom JD, Holick MF, et al. Vitamin D status and response to Vitamin D(3) in obese vs. non-obese African American children. Obesity (Silver Spring). 2008;16:90–95
  7. Zemel MB. Regulation of adiposity and obesity risk by dietary calcium: mechanisms and implications. J Am Coll Nutr. 2002;21:146S–151S
  8. Hey H, Stokholm KH, Lund B, Sorensen OH. Vitamin D deficiency in obese patients and changes in circulating vitamin D metabolites following jejunoileal bypass. Int J Obes. 1982;6:473–479
  9. Parikh SJ, Edelman M, Uwaifo GI, et al. The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab. 2004;89:1196–1199
  10. Chen JS, Sambrook PN, March L, et al. Hypovitaminosis D and parathyroid hormone response in the elderly: effects on bone turnover and mortality. Clin Endocrinol (Oxf). 2008;68:290–298

 Funding: None.

 Conflict of Interest: All authors declare that there are no competing interests to declare.

 Authorship: All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

PII: S0002-9343(09)00534-8

doi: 10.1016/j.amjmed.2009.06.008

The American Journal of Medicine
Volume 122, Issue 11 , Pages 1056-1060 , November 2009

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