The American Journal of Medicine
Volume 122, Issue 9 , Pages 866-873 , September 2009

Incidence, Risk Factors, and Outcomes of Klebsiella pneumoniae Bacteremia

  • Bonnie L. Meatherall, MD

      Affiliations

    • Department of Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    • ,
  • Daniel Gregson, MD

      Affiliations

    • Department of Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    • Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    • ,
  • Terry Ross

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    • ,
  • Johann D.D. Pitout, MD

      Affiliations

    • Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    • ,
  • Kevin B. Laupland, MD

      Affiliations

    • Department of Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    • Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    • Department of Critical Care Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    • Corresponding Author InformationRequests for reprints should be addressed to Kevin B. Laupland, MD, MSc, FRCPC, Room 719, North Tower, Foothills Medical Centre, 1403 29th Street NW, Calgary, Alberta, Canada T2N 2T9

References 

  1. Skogberg K, Lyytikainen O, Ruutu P, et al. Increase in bloodstream infections in Finland, 1995-2002. Epidemiol Infect. 2008;136:108–114Epub 2007 Mar 5
  2. Uslan DZ, Crane SJ, Steckelberg JM, et al. Age- and sex-associated trends in bloodstream infection: a population-based study in Olmsted County, Minnesota. Arch Intern Med. 2007;167:834–839
  3. Yinnon AM, Butnaru A, Raveh D, et al. Klebsiella bacteraemia: community versus nosocomial infection. QJM. 1996;89:933–941
  4. Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev. 1998;11:589–603
  5. Chung DR, Lee SS, Lee HR, et al. Emerging invasive liver abscess caused by K1 serotype Klebsiella pneumoniae in Korea. J Infect. 2007;54:578–583
  6. Fang CT, Lai SY, Yi WC, et al. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin Infect Dis. 2007;45:284–293
  7. Fung CP, Chang FY, Lee SC, et al. A global emerging disease of Klebsiella pneumoniae liver abscess: is serotype K1 an important factor for complicated endophthalmitis?. Gut. 2002;50:420–424
  8. Wang JH, Liu YC, Lee SS, et al. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin Infect Dis. 1998;26:1434–1438
  9. Paterson DL, Hujer KM, Hujer AM, et al. Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases. Antimicrob Agents Chemother. 2003;47:3554–3560
  10. Kang CI, Kim SH, Bang JW, et al. Community-acquired versus nosocomial Klebsiella pneumoniae bacteremia: clinical features, treatment outcomes, and clinical implication of antimicrobial resistance. J Korean Med Sci. 2006;21:816–822
  11. Tsay RW, Siu LK, Fung CP, Chang FY. Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infection. Arch Intern Med. 2002;162:1021–1027
  12. Wang LS, Lee FY, Cheng DL, et al. Klebsiella pneumoniae bacteremia: analysis of 100 episodes. J Formos Med Assoc. 1990;89:756–763
  13. Yang PY, Huang CC, Leu HS, et al. Klebsiella pneumoniae bacteremia: community-acquired vs. nosocomial infections. Chang Gung Med J. 2001;24:688–696
  14. Panhotra BR, Saxena AK, Al-Ghamdi AM. Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae hospital acquired bacteremia (Risk factors and clinical outcome). Saudi Med J. 2004;25:1871–1876
  15. Pitout JD, Gregson DB, Church DL, Laupland KB. Population-based laboratory surveillance for AmpC beta-lactamase-producing Escherichia coli, Calgary. Emerg Infect Dis. 2007;13:443–448
  16. Pitout JD, Hanson ND, Church DL, Laupland KB. Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum beta-lactamases: importance of community isolates with blaCTX-M genes. Clin Infect Dis. 2004;38:1736–1741
  17. Calgary Health Region. Health systems analysis: demographic data. Population by Alberta regional health authorities. http://www.calgaryhealthregion.caAccessed February 4, 2008
  18. Alberta Health Services. Health System Analysis: Demographic Data. http://www.calgaryhealthregion.caAccessed February 4, 2008
  19. Southern Alberta Clinic. Epidemiology of HIV. http://www.calgaryhealthregion.ca/clin/sac/epidemio.htmAccessed November 15, 2007
  20. ALTRA Southern Alberta Transplant Program. http://www.calgaryhealthregion.ca/altra/index.htmAccessed November 15, 2007
  21. Manns BJ, Mortis GP, Taub KJ, et al. The Southern Alberta Renal Program database: a prototype for patient management and research initiatives. Clin Invest Med. 2001;24:164–170
  22. Alberta Diabetes Surveillance System. www.albertadiabetes.caAccessed November 25, 2008
  23. The Parkinson's Society of Alberta. www.parkinsonalberta.caAccessed November 25, 2008
  24. Beck CA, Metz LM, Svenson LW, Patten SB. Regional variation of multiple sclerosis prevalence in Canada. Mult Scler. 2005;11:516–519
  25. Statistical report on the health of Canadians. http://www.phac-aspc.gc.ca/ph-sp/report-rapport/stat/pdf/all_english.pdf1999;Accessed November 25, 2008
  26. Marrett LD, De P, Airia P, Dryer D. Cancer in Canada in 2008. CMAJ. 2008;179:1163–1170
  27. Patten SB, Charney DA. Alcohol consumption and major depression in the Canadian population. Can J Psychiatry. 1998;43:502–506
  28. Remis RS, Hogg R, Krahn MD, et al. Report to Health Canada. Estimating the number of blood transfusion recipients infected by hepatitis C virus in Canada, 1960-85 and 1990-1992. http://www.phac-aspc.gc.ca/hepc/pubs/hivhcv-vhcvih/index-eng.php1998;Accessed November 25, 2008
  29. Zhang J, Zou S, Giulivi A. Epidemiology of hepatitis B in Canada. Can J Infect Dis. 2001;12:345–350
  30. Digestive Diseases Statistics (National Institute of Diabetes and Digestive and Kidney Diseases). http://www2.niddk.nih.gov/AboutNIDDK/ReportsAndStrategicPlanning/BurdenOfDisease/DigestiveDiseases/.Accessed November 25, 2008
  31. Bernstein CN, Wajda A, Svenson LW, et al. The epidemiology of inflammatory bowel disease in Canada: a population-based study. Am J Gastroenterol. 2006;101:1559–1568
  32. Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038–2047
  33. Gabriel SE, Crowson CS, O'Fallon WM. The epidemiology of rheumatoid arthritis in Rochester, Minnesota, 1955-1985. Arthritis Rheum. 1999;42:415–420
  34. Hochberg MC, Perlmutter DL, Medsger TA, et al. Prevalence of self-reported physician-diagnosed systemic lupus erythematosus in the USA. Lupus. 1995;4:454–456
  35. Laupland KB, Church DL, Mucenski M, et al. Population-based study of the epidemiology of and the risk factors for invasive Staphylococcus aureus infections. J Infect Dis. 2003;187:1452–1459
  36. Laupland KB, Church DL, Ross T, Pitout JD. Population-based laboratory surveillance of Hafnia alvei isolates in a large Canadian health region. Ann Clin Microbiol Antimicrob. 2006;5:12
  37. Laupland KB, Parkins MD, Gregson DB, et al. Population-based laboratory surveillance for Serratia species isolates in a large Canadian health region. Eur J Clin Microbiol Infect Dis. 2008;27:89–95
  38. Al-Hasan MN, Wilson JW, Lahr BD, et al. Incidence of Pseudomonas aeruginosa bacteremia: a population-based study. Am J Med. 2008;121:702–708
  39. Laupland KB, Gregson DB, Church DL, et al. Incidence, risk factors and outcomes of Escherichia coli bloodstream infections in a large Canadian region. Clin Microbiol Infect. 2008;14:1041–1047
  40. Laupland KB, Ross T, Church DL, Gregson DB. Population-based surveillance of invasive pyogenic streptococcal infection in a large Canadian region. Clin Microbiol Infect. 2006;12:224–230
  41. James MT, Laupland KB, Tonelli M, et al. Risk of bloodstream infection in patients with chronic kidney disease not treated with dialysis. Arch Intern Med. 2008;168:2333–2339
  42. Paterson DL, Ko WC, Von Gottberg A, et al. Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases. Clin Infect Dis. 2004;39:31–37
  43. Goossens H. MYSTIC program: summary of European data from 1997 to 2000. Diagn Microbiol Infect Dis. 2001;41:183–189
  44. Ko WC, Paterson DL, Sagnimeni AJ, et al. Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns. Emerg Infect Dis. 2002;8:160–166

 Funding: This study was funded in part by an unrestricted research grant from Pfizer Canada. The authors had complete autonomy of the design, acquisition, analysis, and reporting of the study.

 Conflict of Interest: None of the authors have any conflicts of interest associated with the work presented in this manuscript.

 Authorship: All authors had access to the data and played a role in writing this manuscript.

PII: S0002-9343(09)00524-5

doi: 10.1016/j.amjmed.2009.03.034

The American Journal of Medicine
Volume 122, Issue 9 , Pages 866-873 , September 2009

Article Tools

* Image Usage & Resolution