The American Journal of Medicine
Volume 122, Issue 9 , Pages 830-832 , September 2009

More Than Skin Deep

  • Ioannis Protopsaltis, MD

      Affiliations

    • Department of Internal Medicine, Tzanio General Hospital of Piraeus, Piraeus, Greece
    • ,
  • Angeliki Angelidi, MD

      Affiliations

    • Department of Internal Medicine, Tzanio General Hospital of Piraeus, Piraeus, Greece
    • ,
  • Haralampos Milionis, MD, PhD

      Affiliations

    • School of Medicine, University of Ioannina, Ioannina, Greece
    • Corresponding Author InformationRequests for reprints should be addressed to Haralampos J. Milionis, MD, Department of Internal Medicine, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece
    • ,
  • Ioannis Katsantonis, MD

      Affiliations

    • Department of Internal Medicine, Tzanio General Hospital of Piraeus, Piraeus, Greece
    • ,
  • Paraskevi Gavra, MD

      Affiliations

    • Department of Internal Medicine, Tzanio General Hospital of Piraeus, Piraeus, Greece
    • ,
  • Adamantia Zizi-Sermpetzoglou, MD

      Affiliations

    • Department of Internal Medicine, Tzanio General Hospital of Piraeus, Piraeus, Greece
    • ,
  • Despina Perimeni, MD

      Affiliations

    • Department of Internal Medicine, Tzanio General Hospital of Piraeus, Piraeus, Greece
    • ,
  • Nikolaos Paschalidis, MD

      Affiliations

    • Department of Internal Medicine, Tzanio General Hospital of Piraeus, Piraeus, Greece

References 

  1. Brunsting LA, Goeckerman WH, O'Leary PA. Pyoderma (echthyma) gangrenosum: clinical and experimental observations in five cases occurring in adults. Arch Dermatol Syphilol. 1930;22:655–680
  2. Powell FC, Su WP, Perry HO. Pyoderma gangrenosum: classification and management. J Am Acad Dermatol. 1996;34:395–409quiz 410-392
  3. Crowson AN, Mihm MC, Magro C. Pyoderma gangrenosum: a review. J Cutan Pathol. 2003;30:97–107
  4. Callen JP. Pyoderma gangrenosum. Lancet. 1998;351(9102):581–585
  5. Ahmadi S, Powell FC. Pyoderma gangrenosum: uncommon presentations. Clin Dermatol. 2005;23:612–620
  6. Powell FC, Schroeter AL, Su WP, Perry HO. Pyoderma gangrenosum: a review of 86 patients. Q J Med. 1985;55:173–186
  7. Weenig RH, Davis MD, Dahl PR, Su WP. Skin ulcers misdiagnosed as pyoderma gangrenosum. N Engl J Med. 2002;347:1412–1418
  8. Tay CH. Letter: Pyoderma gangrenosum and leukemia. Arch Dermatol. 1973;108:580–581
  9. von den Driesch P. Pyoderma gangrenosum: a report of 44 cases with follow-up. Br J Dermatol. 1997;137:1000–1005
  10. Charles CA, Bialy TL, Falabella AF, et al. Poor prognosis of arthritis-associated pyoderma gangrenosum. Arch Dermatol. 2004;140:861–864
  11. Daoud MS, Lust JA, Kyle RA, Pittelkow MR. Monoclonal gammopathies and associated skin disorders. J Am Acad Dermatol. 1999;40:507–535quiz 536-508
  12. Yates P, Corbett G, Stockdill G. Pyoderma gangrenosum and myelodysplasia. Clin Lab Haematol. 1987;9:425–428
  13. Franca AE, Salvino LK, Leite SH, et al. Pyoderma gangrenosum as first clinical manifestation of gastric adenocarcinoma. J Eur Acad Dermatol Venereol. 2006;20:440–441
  14. Gallo R, Parodi A, Rebora A. Pyoderma gangrenosum in a patient with gastric carcinoma. Int J Dermatol. 1995;34:713–714
  15. Langan SM, Powell FC. Vegetative pyoderma gangrenosum: a report of two new cases and a review of the literature. Int J Dermatol. 2005;44:623–629
  16. Brooklyn TN, Dunnill MG, Shetty A, et al. Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial. Gut. 2006;55:505–509
  17. Heffernan MP, Anadkat MJ, Smith DI. Adalimumab treatment for pyoderma gangrenosum. Arch Dermatol. 2007;143:306–308
  18. Balkwill F. Tumor necrosis factor or tumor promoting factor?. Cytokine Growth Factor Rev. 2002;13:135–141
  19. Zins K, Abraham D, Sioud M, Aharinejad S. Colon cancer cell-derived tumor necrosis factor-α mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway. Cancer Res. 2007;67:1038–1045

 Parwathi “Uma” Paniker, MD, Section Editor

 Funding: None.

 Conflicts of Interest: None.

 Authorship: The work presented here is original and has not been submitted for publication elsewhere. All authors contributed to the preparation of this document and accept responsibility for its scientific content.

PII: S0002-9343(09)00407-0

doi: 10.1016/j.amjmed.2009.05.002

The American Journal of Medicine
Volume 122, Issue 9 , Pages 830-832 , September 2009

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