The American Journal of Medicine
Volume 122, Issue 8 , Pages 778.e1-778.e7 , August 2009

Self-reported Antibiotic Allergy Incidence and Prevalence: Age and Sex Effects

  • Eric Macy, MD

      Affiliations

    • Department of Allergy, Southern California Permanente Medical Group, San Diego Medical Center, San Diego, Calif
    • Corresponding Author InformationRequests for reprints should be addressed to Eric Macy, MD, Department of Allergy, Kaiser Permanente, 7060 Clairemont Mesa Blvd., San Diego, CA 92111
    • ,
  • T. Poon K-Y, MS

      Affiliations

    • Department of Research and Evaluation, Kaiser Permanente Health Care Program, Pasadena, Calif

References 

  1. Dykewicz MS. Drug allergy. Compr Ther. 1996;22:353–559
  2. Macy E, Mellon MH, Schatz M, Patterson R. Drug allergy. In:  Adelman DC,  Casale TB,  Corren J editor. Manual of Allergy and Immunology. 4th edition. Philadelphia, PA: Lippincott Williams & Wilkins; 2002;p. 219–241
  3. Gomes ER, Demoly P. Epidemiology of hypersensitivity reactions. Curr Opin Clin Immunol. 2005;5:309–316
  4. Guglielmi L, Guglielmi P, Demoly P. Drug hypersensitivity: epidemiology and risk factors. Curr Pharm Des. 2006;12:3309–3312
  5. Kando JC, Yonkers KA, Cole JO. Gender as a risk factor for adverse events to medications. Drugs. 1995;50:1–6
  6. Domecq C, Naranjo CA, Ruiz I, Busto U. Sex-related variations in the frequency and characteristics of adverse drug reactions. Int J Clin Pharmacol Ther Toxicol. 1980;18:362–366
  7. Shehab N, Patel PR, Srinivasan A, Budnitz DS. Emergency department visits for antibiotic-associated adverse events. Clin Infect Dis. 2008;47:735–743
  8. Gonzalez R, Malone DC, Maselli JH, Sande MA. Excessive antibiotic use for acute respiratory infections in the United States. Clin Infect Dis. 2001;33:757–762
  9. Apter AJ, Kinman JL, Bilker WB, et al. Represcription of penicillin after allergic-like events. J Allergy Clin Immunol. 2004;113:764–770
  10. Strom BL, Schinnar R, Apter AJ, et al. Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics. N Engl J Med. 2003;349:1628–1635
  11. Bigby M, Jick S, Jick H, Arndt K. Drug-induced cutaneous reactions (A report fron the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982). JAMA. 1986;256:3358–3363
  12. Bigby M. Rates of cutaneous reactions to drugs. Arch Dermatol. 2001;137:765–770
  13. Iannini P, Mandell L, Felmingham J, et al. Adverse cutaneous reactions and drugs: a focus on antimicrobials. J Chemother. 2006;18:127–139
  14. Gomes E, Cardoso MF, Praca F, et al. Self-reported drug allergy in a general adult Portuguese population. Clin Exp Allergy. 2004;34:1597–1601
  15. Lange L, Koningsbruggen SV, Rietschel E. Questionnaire-based survey of lifetime-prevalence and character of allergic drug reactions in German children. Pediatr Allergy Immunol. 2008;19(7):634–638
  16. Hung OR, Bands C, Laney G, et al. Drug allergies in the surgical population. Can J Anaesth. 1994;41:1133–1139
  17. Honigman B, Lee J, Rothschild J, et al. Using computerized data to identify adverse drug events in outpatients. J Am Med Inform Assoc. 2001;8:254–266
  18. Johannes CB, Ziyadeh N, Seeger JD, et al. Incidence of allergic reactions associated with antibiotic use in a large, managed care organisation. Drug Saf. 2007;30:705–713
  19. Naldi L, Conforti A, Venegoni M, et al. Cutaneous reactions to drugs (An analysis of spontaneous reports in four Italian regions). Br J Clin Pharmacol. 1999;48:839–846
  20. Cantrell R, Young AF, Martin BC. Antibiotic prescribing in ambulatory care setting for adults with colds, upper respiratory tract infections, and bronchitis. Clin Ther. 2002;24:170–182
  21. Jhung MA, Budnitz DS, Mendelsohn AB, et al. Evaluation and overview of the National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance Project (NEISS-CADES). Med Care. 2007;45:S96–S102
  22. Macy E, Schatz M, Lin C, Poon KYT. The falling rate of positive penicillin skin tests from 1995 to 2007. The Permanente Journal. 2009;13:12–19
  23. Arroliga ME, Radojicic C, Gordon SM, et al. A prospective observational study on the effect of penicillin skin testing on antibiotic use in the intensive care unit. Infect Control Hosp Epidemiol. 2003;24:347–350
  24. Park MA, Matesic D, Markus PJ, Li JTC. Female sex as a risk factor for penicillin allergy. Ann Allergy Asthma Immunol. 2007;99:54–58
  25. Macy E, Roppe L, Schatz M. Routine penicillin skin testing in hospitalized patients with a history of penicillin allergy. The Permanente Journal. 2004;8:20–24
  26. Lin D, Li WK, Rieder MJ. Cotrimoxazole for prophylaxis or treatment of opportunistic infections of HIV/AIDS in patients with previous history of hypersensitivity to cotrimoxazole. Cochrane Database Syst Rev. 2007;(2):CD005646

 Funding: Kaiser Permanente Health Care Program.

 Conflict of Interest: None.

 Authorship: All authors had access to the data and a role in writing the manuscript.

PII: S0002-9343(09)00343-X

doi: 10.1016/j.amjmed.2009.01.034

The American Journal of Medicine
Volume 122, Issue 8 , Pages 778.e1-778.e7 , August 2009

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