The American Journal of Medicine
Volume 122, Issue 9 , Pages 836-842 , September 2009

Do NSAIDs Affect Longitudinal Changes in Knee Cartilage Volume and Knee Cartilage Defects in Older Adults?

  • Changhai Ding, MD

      Affiliations

    • Menzies Research Institute, University of Tasmania, Hobart, Australia
    • Department of Epidemiology and Preventive Medicine, Monash University Medical School, Melbourne, Australia
    • Corresponding Author InformationRequests for reprints should be addressed to Changhai Ding, MD, Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    • ,
  • Flavia Cicuttini, PhD

      Affiliations

    • Department of Epidemiology and Preventive Medicine, Monash University Medical School, Melbourne, Australia
    • ,
  • Graeme Jones, MD

      Affiliations

    • Menzies Research Institute, University of Tasmania, Hobart, Australia

  • Image Result

    Comparison of tibial cartilage loss per annum over 2.9 years between use of selective COX-2 inhibitors and use of conventional NSAIDs. Cartilage loss was adjusted for sex, age, body mass index, knee p

    Comparison of tibial cartilage loss per annum over 2.9 years between use of selective COX-2 inhibitors and use of conventional NSAIDs. Cartilage loss was adjusted for sex, age, body mass index, knee pain, smoking, lower-limb muscle strength, baseline cartilage volume, tibial bone area, subchondral bone marrow edema, radiographic osteoarthritis, and rheumatoid arthritis.

 Funding: National Health and Medical Research Council of Australia; Arthritis Foundation of Australia; Tasmanian Community Fund; University of Tasmania Grant-Institutional Research Scheme.

 Conflict of Interest: Dr. Jones has worked as a consultant, speaker, and clinical trialist with Pfizer, MSD, Roche, and Novartis, all of which manufacture NSAIDs. However, none of these companies had any input into the writing of this article. Other authors have nothing to declare.

 Authorship: All authors had access to the data in the study. Study design: Ding, Cicuttini, Jones. Acquisition of data: Ding, Jones. Analysis and interpretation of data: Ding, Cicuttini, Jones. Manuscript preparation: Ding, Cicuttini, Jones. Statistical analysis: Ding, Jones.

PII: S0002-9343(09)00341-6

doi: 10.1016/j.amjmed.2009.03.022

The American Journal of Medicine
Volume 122, Issue 9 , Pages 836-842 , September 2009

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