The American Journal of Medicine
Volume 122, Issue 7 , Pages 656-663.e1 , July 2009

Breastfeeding in Infancy and Adult Cardiovascular Disease Risk Factors

  • Nisha I. Parikh, MD, MPH

      Affiliations

    • The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass
    • Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Mass
    • ,
  • Shih-Jen Hwang, PhD

      Affiliations

    • The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass
    • National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md
    • ,
  • Erik Ingelsson, MD, PhD

      Affiliations

    • The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass
    • ,
  • Emelia J. Benjamin, MD, ScM

      Affiliations

    • The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass
    • Preventive Medicine and Cardiology Sections, Boston University School of Medicine, Boston, Mass
    • Epidemiology Section, Boston University School of Public Health, Boston, Mass
    • ,
  • Caroline S. Fox, MD, MPH

      Affiliations

    • The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass
    • National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md
    • Brigham and Women's Hospital, Harvard Medical School, Boston, Mass
    • ,
  • Ramachandran S. Vasan, MD

      Affiliations

    • The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass
    • Preventive Medicine and Cardiology Sections, Boston University School of Medicine, Boston, Mass
    • ,
  • Joanne M. Murabito, MD, ScM

      Affiliations

    • The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass
    • Section of General Internal Medicine, Boston University School of Medicine, Boston, Mass
    • Corresponding Author InformationRequests for reprints should be addressed to Joanne M. Murabito, MD, ScM, 73 Mount Wayte Ave, #2, Framingham, MA 01702

References 

  1. Gartner LM, Morton J, Lawrence RA, et al. Breastfeeding and the use of human milk. Pediatrics. 2005;115:496–506
  2. Office of Women's Health. US Department of Health and Human Services 2006. http://www.womenshealth.gov/breastfeeding/index.cfm?page=CampaignLast accessed October 17, 2006.
  3. Primary care interventions to promote breastfeeding: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2008;149:560–564
  4. Martin RM, Ben Shlomo Y, Gunnell D, et al. Breast feeding and cardiovascular disease risk factors, incidence, and mortality: the Caerphilly study. J Epidemiol Community Health. 2005;59:121–129
  5. Owen CG, Whincup PH, Odoki K, et al. Infant feeding and blood cholesterol: a study in adolescents and a systematic review. Pediatrics. 2002;110:597–608
  6. Owen CG, Whincup PH, Gilg JA, Cook DG. Effect of breast feeding in infancy on blood pressure in later life: systematic review and meta-analysis. BMJ. 2003;327:1189–1195
  7. Owen CG, Martin RM, Whincup PH, et al. The effect of breastfeeding on mean body mass index throughout life: a quantitative review of published and unpublished observational evidence. Am J Clin Nutr. 2005;82:1298–1307
  8. Ravelli AC, van der Meulen JH, Osmond C, et al. Infant feeding and adult glucose tolerance, lipid profile, blood pressure, and obesity. Arch Dis Child. 2000;82:248–252
  9. Rudnicka AR, Owen CG, Strachan DP. The effect of breastfeeding on cardiorespiratory risk factors in adult life. Pediatrics. 2007;119:e1107–e1115
  10. Rich-Edwards JW, Stampfer MJ, Manson JE, et al. Breastfeeding during infancy and the risk of cardiovascular disease in adulthood. Epidemiology. 2004;15:550–556
  11. Martin RM, Ness AR, Gunnell D, et al. Does breast-feeding in infancy lower blood pressure in childhood? (The Avon Longitudinal Study of Parents and Children (ALSPAC)). Circulation. 2004;109:1259–1266
  12. Michels KB, Willett WC, Graubard BI, et al. A longitudinal study of infant feeding and obesity throughout life course. Int J Obes (Lond). 2007;31:1078–1085Epub 2007 Apr 24
  13. Dawber TR, Kannel WB. An approach to longitudinal studies in a community: the Framingham Study. Ann N Y Acad Sci. 1963;107:539–556
  14. Feinleib M, Kannel WB, Garrison RJ, et al. The Framingham Offspring Study (Design and preliminary data). Prev Med. 1975;4:518–525
  15. Murabito JM, Evans JC, Larson MG, et al. Family breast cancer history and mammography: Framingham Offspring Study. Am J Epidemiol. 2001;154:916–923
  16. Kannel WB, Feinleib M, McNamara PM, et al. An investigation of coronary heart disease in families (The Framingham Offspring Study). Am J Epidemiol. 1979;110:281–290
  17. McNamara JR, Schaefer EJ. Automated enzymatic standardized lipid analyses for plasma and lipoprotein fractions. Clin Chim Acta. 1987;166:1–8
  18. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  19. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults—The Evidence Report (National Institutes of Health). Obes Res. 1998;6(Suppl 2):51S–209S
  20. WHO Consultation on Obesity. Obesity: Preventing and Managing the Global Epidemic. Geneva, Switzerland: World Health Organization: WHO Technical Report Series 894; 2000;
  21. Kannel WB, Sorlie P. Some health benefits of physical activity (The Framingham Study). Arch Intern Med. 1979;139:857–861
  22. Sherman SE, D'Agostino RB, Cobb JL, Kannel WB. Physical activity and mortality in women in the Framingham Heart Study. Am Heart J. 1994;128:879–884
  23. Cupples LA, D'Agostino RB. Some risk factors related to the annual incidence of cardiovascular disease and death using pooled repeated biennial measurements: Framingham Study, 30-year follow-up. In:  Kannel WB,  Wolf PA,  Garrison RJ editor. The Framingham Heart Study: An Epidemiologic Investigation of Cardiovascular Disease. Washington, DC: NIH Publication; 1987;p. 87–203
  24. Arenz S, Ruckerl R, Koletzko B, von Kries R. Breast-feeding and childhood obesity—a systematic review. Int J Obes Relat Metab Disord. 2004;28:1247–1256
  25. Gillman MW, Rifas-Shiman SL, Berkey CS, et al. Breast-feeding and overweight in adolescence. Epidemiology. 2006;17:112–114
  26. Victora CG, Barros F, Lima RC, et al. Anthropometry and body composition of 18 year old men according to duration of breast feeding: birth cohort study from Brazil. BMJ. 2003;327:901
  27. Rudnicka AR, Owen CG, Strachan DP. The effect of breastfeeding on cardiorespiratory risk factors in adult life. Pediatrics. 2007;119:e1107–e1115
  28. McGuire W, Anthony MY. Formula milk versus term human milk for feeding preterm or low birth weight infants. Cochrane Database Syst Rev. 2001;CD002971
  29. Butte NF, Wong WW, Hopkinson JM, et al. Infant feeding mode affects early growth and body composition. Pediatrics. 2000;106:1355–1366
  30. Dewey KG, Heinig MJ, Nommsen LA, et al. Growth of breast-fed and formula-fed infants from 0 to 18 months: the DARLING Study. Pediatrics. 1992;89(6 Pt 1):1035–1041
  31. Michaelsen KF, Larsen PS, Thomsen BL, Samuelson G. The Copenhagen Cohort Study on Infant Nutrition and Growth: breast-milk intake, human milk macronutrient content, and influencing factors. Am J Clin Nutr. 1994;59:600–611
  32. Coady SA, Jaquish CE, Fabsitz RR, et al. Genetic variability of adult body mass index: a longitudinal assessment in Framingham families. Obes Res. 2002;10:675–681
  33. Mayer-Davis EJ, Rifas-Shiman SL, Zhou L, et al. Breast-feeding and risk for childhood obesity: does maternal diabetes or obesity status matter?. Diabetes Care. 2006;29:2231–2237
  34. Fak F, Friis-Hansen L, Westrom B, Wierup N. Gastric ghrelin cell development is hampered and plasma ghrelin is reduced by delayed weaning in rats. J Endocrinol. 2007;192:345–352
  35. Miralles O, Sanchez J, Palou A, Pico C. A physiological role of breast milk leptin in body weight control in developing infants. Obesity (Silver Spring). 2006;14:1371–1377
  36. Dundar NO, Anal O, Dundar B, et al. Longitudinal investigation of the relationship between breast milk leptin levels and growth in breast-fed infants. J Pediatr Endocrinol Metab. 2005;18:181–187
  37. Singhal A, Farooqi IS, O'Rahilly S, et al. Early nutrition and leptin concentrations in later life. Am J Clin Nutr. 2002;75:993–999
  38. Bronsky J, Karpisek M, Bronska E, et al. Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein: proteins newly identified in human breast milk. Clin Chem. 2006;52:1763–1770
  39. Singhal A, Cole TJ, Fewtrell M, Lucas A. Breastmilk feeding and lipoprotein profile in adolescents born preterm: follow-up of a prospective randomised study. Lancet. 2004;363:1571–1578
  40. Demakakos P, Nazroo J, Breeze E, Marmot M. Socioeconomic status and health: the role of subjective social status. Soc Sci Med. 2008;67:330–340
  41. Maty SC, Lynch JW, Raghunathan TE, Kaplan GA. Childhood socioeconomic position, gender, adult body mass index, and incidence of type 2 diabetes mellitus over 34 years in the Alameda County Study. Am J Public Health. 2008;98:1486–1494
  42. Linn S, Fulwood R, Carroll M, et al. Serum total cholesterol: HDL cholesterol ratios in US white and black adults by selected demographic and socioeconomic variables (HANES II). Am J Public Health. 1991;81:1038–1043
  43. Kolacek S, Kapetanovic T, Luzar V. Early determinants of cardiovascular risk factors in adults (B. Blood pressure). Acta Paediatr. 1993;82:377–382
  44. Leeson CP, Kattenhorn M, Deanfield JE, Lucas A. Duration of breast feeding and arterial distensibility in early adult life: population based study. BMJ. 2001;322:643–647
  45. Lawlor DA, Riddoch CJ, Page AS, et al. Infant feeding and components of the metabolic syndrome: findings from the European Youth Heart Study. Arch Dis Child. 2005;90:582–588
  46. Kark JD, Troya G, Friedlander Y, et al. Validity of maternal reporting of breast feeding history and the association with blood lipids in 17 year olds in Jerusalem. J Epidemiol Community Health. 1984;38:218–225
  47. Troy LM, Michels KB, Hunter DJ, et al. Self-reported birthweight and history of having been breastfed among younger women: an assessment of validity. Int J Epidemiol. 1996;25:122–127
  48. Lande B, Andersen LF, Henriksen T, et al. Relations between high ponderal index at birth, feeding practices and body mass index in infancy. Eur J Clin Nutr. 2005;59:1241–1249
  49. Braveman PA, Cubbin C, Egerter S, et al. Socioeconomic status in health research: one size does not fit all. JAMA. 2005;294:2879–2888
  50. Buring JE, O'Connor GT, Goldhaber SZ, et al. Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction. Circulation. 1992;85:22–29
  51. Lloyd-Jones DM, Leip EP, Larson MG, et al. Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age. Circulation. 2006;113:791–798
  52. Calle EE, Thun MJ, Petrelli JM, et al. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999;341:1097–1105
  53. Kenchaiah S, Evans JC, Levy D, et al. Obesity and the risk of heart failure. N Engl J Med. 2002;347:305–313
  54. Martin JA, Hamilton BE, Sutton PD, et al. Births: final data for 2004. Natl Vital Stat Rep. 2006;55:1–101

 Funding: Supported by a National Institute of Health/National Heart, Lung, and Blood Institute, contract N01-HC-25195, 2K24 HL 04334 (RSV).

 Conflict of Interest: None.

 Authorship: All authors had access to the data and played a role in writing this manuscript.

PII: S0002-9343(09)00290-3

doi: 10.1016/j.amjmed.2008.11.034

The American Journal of Medicine
Volume 122, Issue 7 , Pages 656-663.e1 , July 2009

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