The American Journal of Medicine
Volume 122, Issue 7 , Pages 688-691 , July 2009

Herpes Simplex Type-2 Meningitis: Presentation and Lack of Standardized Therapy

  • Marie L. Landry, MD

      Affiliations

    • Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Conn
    • Corresponding Author InformationRequests for reprints should be addressed to Marie L. Landry, MD, Department of Laboratory Medicine, P.O. Box 208035, Yale University School of Medicine, New Haven, CT 06520-8035
    • ,
  • Jennifer Greenwold, MD

      Affiliations

    • Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Conn
    • Current address: 1493 Cambridge Street, Cambridge, MA 02139.
    • ,
  • Holenarasipur R. Vikram, MD

      Affiliations

    • Division of Infectious Diseases, Mayo Clinic, Scottsdale, Ariz

References 

  1. Tedder DG, Ashley R, Tyler KL, Levin MJ. Herpes simplex virus infection as a cause of benign recurrent lymphocytic meningitis. Ann Intern Med. 1994;121:334–338
  2. Lakeman FD, Whitley RJ. Diagnosis of herpes simplex encephalitis: application of polymerase chain reaction to cerebrospinal fluid from brain-biopsied patients and correlation with disease (National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group). J Infect Dis. 1995;171:857–863
  3. Shalabi M, Whitley RJ. Recurrent benign lymphocytic meningitis. Clin Infect Dis. 2006;43:1194–1197
  4. Cohen BA, Rowley AH, Long CM. Herpes simplex type 2 in a patient with Mollaret's meningitis: demonstration by polymerase chain reaction. Ann Neurol. 1994;35:112–116
  5. Lortholary O, Rozenberg F, Perronne C, et al. Herpes simplex virus type 2 DNA in cerebrospinal fluid of a woman with recurrent meningitis. Clin Infect Dis. 1993;17:941–942
  6. Omland LH, Vestergaard BF, Wandall JH. Herpes simplex virus type 2 infections of the central nervous system: a retrospective study of 49 patients. Scand J Infect Dis. 2008;40:59–62
  7. Schlesinger Y, Tebas P, Gaudreault-Keener M, et al. Herpes simplex virus type 2 meningitis in the absence of genital lesions: improved recognition with use of the polymerase chain reaction. Clin Infect Dis. 1995;20:842–848
  8. Aurelius E, Forsgren M, Gille E, Skoldenberg B. Neurologic morbidity after herpes simplex virus type 2 meningitis: a retrospective study of 40 patients. Scand J Infect Dis. 2002;34:278–283
  9. Godet C, Beby-Defaux A, Agius G, et al. Maternal herpes simplex virus type 2 encephalitis following Cesarean section. J Infect. 2003;47:174–175
  10. Dylewski JS, Bekhor S. Mollaret's meningitis caused by herpes simplex virus type 2: case report and literature review. Eur J Clin Microbiol Infect Dis. 2004;23:560–562
  11. Kupila L, Vuorinen T, Vainionpaa R, et al. Etiology of aseptic meningitis and encephalitis in an adult population. Neurology. 2006;66:75–80
  12. Davies N, Tang J, Ward KN. Herpes simplex virus type 2 and recurrent meningitis. Lancet. 2004;364(9433):501–502

 Funding: None.

 Conflict of Interest: None.

 Authorship: All authors had access to the data and a role in writing the manuscript.

PII: S0002-9343(09)00289-7

doi: 10.1016/j.amjmed.2009.02.017

The American Journal of Medicine
Volume 122, Issue 7 , Pages 688-691 , July 2009

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