The American Journal of Medicine
Volume 122, Issue 6 , Pages 516-518 , June 2009

An Obscure Harbinger

  • James M. McCabe, MD

      Affiliations

    • Division of Cardiology, University of California, San Francisco School of Medicine, San Francisco, CA
    • Corresponding Author InformationRequests for reprints should be addressed to James M. McCabe, MD, 505 Parnassus Avenue, Box 0124, San Francisco, CA 94143-0124
    • ,
  • Uma Mahadevan, MD

      Affiliations

    • Division of Gastroenterology, University of California, San Francisco School of Medicine, San Francisco, CA
    • ,
  • Arpana Vidyarthi

      Affiliations

    • Department of Internal Medicine, University of California, San Francisco School of Medicine, San Francisco, CA

References 

  1. Bargen JA, Barker NW. Extensive arterial and venous thrombosis complicating chronic ulcerative colitis. Arch Intern Med. 1936;58:17–31
  2. Jackson LM, O'Gorman PJ, O'Connell J, et al. Thrombosis in inflammatory bowel disease: clinical setting, procoagulant profile and factor V Leiden. QJM. 1997;90:183–188
  3. Koutroubakis IE. Role of thrombotic vascular risk factors in inflammatory bowel disease. Dig Dis. 2000;18:161–167
  4. Koutroubakis IE. Therapy insight: Vascular complications in patients with inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol. 2005;2:266–272
  5. Papa A, Danese S, Grillo A, et al. Review article: inherited thrombophilia in inflammatory bowel disease. Am J Gastroenterol. 2003;98:1247–1251
  6. Sonoda K, Ikeda S, Mizuta Y, et al. Evaluation of venous thromboembolism and coagulation-fibrinolysis markers in Japanese patients with inflammatory bowel disease. J Gastroenterol. 2004;39:948–954
  7. Bernstein CN, Blanchard JF, Houston DS, Wajda A. The incidence of deep venous thrombosis and pulmonary embolism among patients with inflammatory bowel disease: a population-based cohort study. Thromb Haemost. 2001;85:430–434
  8. Thornton M, Solomon MJ. Crohn's disease: in defense of a microvascular etiology. Int J Colorectal Dis. 2002;17:287–297
  9. Solem CA, Loftus EV, Tremaine WJ, Sandborn WJ. Venous thromboembolism in inflammatory bowel disease. Am J Gastroenterol. 2004;99:97–101
  10. Graef V, Baggenstoss AH, Sauer WG, Spittell JA. Venous thrombosis occurring in nonspecific ulcerative colitis: a necropsy study. Arch Intern Med. 1966;117:377–382
  11. Magro F, Dinis-Ribeiro M, Araújo FM, et al. High prevalence of combined thrombophilic abnormalities in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2003;15:1157–1163
  12. Srirajaskanthan R, Winter M, Muller AF. Venous thrombosis in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2005;17:697–700
  13. Yilmaz S, Bayan K, Tüzün Y, et al. A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: data from Turkey. J Thromb Thrombolysis. 2006;22:205–212
  14. Loftus EV. Management of extraintestinal manifestations and other complications of inflammatory bowel disease. Curr Gastroenterol Rep. 2004;6:506–513
  15. Zezos P, Papaioannou G, Nikolaidis N, et al. Low-molecular-weight heparin (enoxaparin) as adjuvant therapy in the treatment of active ulcerative colitis: a randomized, controlled, comparative study. Aliment Pharmacol Ther. 2006;23:1443–1453
  16. Chande N, McDonald JW, MacDonald JK. Unfractionated or low-molecular-weight heparin for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2008;16:CD006774

 Aimee K. Zaas, MD, Section Editor

 Funding: None.

 Conflict of Interest: None.

 Authorship: All authors have had access to the data and have reviewed this manuscript.

PII: S0002-9343(09)00111-9

doi: 10.1016/j.amjmed.2009.02.003

The American Journal of Medicine
Volume 122, Issue 6 , Pages 516-518 , June 2009

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