The American Journal of Medicine
Volume 122, Issue 6 , Pages 550-558 , June 2009

Exceptional Mortality Prediction by Risk Scores from Common Laboratory Tests

  • Benjamin D. Horne, PhD, MPH

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Genetic Epidemiology Division, Department of Biomedical Informatics, University of Utah, Salt Lake City
    • Corresponding Author InformationRequests for reprints should be addressed to Benjamin D. Horne, PhD, MPH, Cardiovascular Department, Intermountain Medical Center, 5121 S. Cottonwood St, Murray, UT 84157
    • ,
  • Heidi T. May, PhD, MSPH

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • ,
  • Joseph B. Muhlestein, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City
    • ,
  • Brianna S. Ronnow, MS

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • ,
  • Donald L. Lappé, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City
    • ,
  • Dale G. Renlund, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City
    • ,
  • Abdallah G. Kfoury, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • ,
  • John F. Carlquist, PhD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City
    • ,
  • Patrick W. Fisher, DO, PhD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • ,
  • Robert R. Pearson, PharmD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Current address: Clinical Development and Medical Affairs, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709.
    • ,
  • Tami L. Bair, BS

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • ,
  • Jeffrey L. Anderson, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City

References 

  1. Ringquist I, Fisher LD, Mock M, et al. Prognostic value of angiographic indices of coronary artery disease from the Coronary Artery Surgery Study (CASS). J Clin Invest. 1983;71:1854–1866
  2. Liao L, Kong DF, Shaw LK, et al. A new anatomic score for prognosis after cardiac catheterization in patients with previous bypass surgery. J Am Coll Cardiol. 2005;46:1684–1692
  3. Zimmerman JE, Kramer AA, McNair DS, Malila FM. Acute physiology and chronic health evaluation (APACHE) IV: hospital mortality assessment for today's critically ill patients. Crit Care Med. 2006;34:1297–1310
  4. Edwards FH, Grover FL, Shroyer ALW, et al. The Society of Thoracic Surgeons national cardiac surgery database: current risk assessment. Ann Thorac Surg. 1997;63:903–908
  5. Rothwell PM, Giles MF, Flossmann E, et al. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet. 2005;366:29–36
  6. Wilson PWF, D'Agostino RB, Levy D, et al. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837–1847
  7. Anderson JL, Ronnow BS, Horne BD, et al. A complete blood count-derived risk score greatly improves cardiovascular predictive ability. Am J Cardiol. 2007;99:169–174
  8. McQuillan GM, Gunter EW, Lannom L. Field issues for the plan and operation of the laboratory component of the Third National Health and Nutrition Examination Survey. J Nutr. 1990;120:1446–1450
  9. Neaton JD, Wentworth D Multiple Risk Factor Intervention Trial Research Group. Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease (Overall findings and differences by age for 316,099 white men). Arch Intern Med. 1992;152:56–64
  10. Shaten BJ, Kuller LH, Kjelsberg MO, et al. Lung cancer mortality after 16 years in MRFIT participants in intervention and usual-care groups (Multiple Risk Factor Intervention Trial). Ann Epidemiol. 1997;7:125–136
  11. Dankner R, Goldbourt U, Boyko V, Reicher-Reiss H BIP Study Group. Predictors of cardiac and noncardiac mortality among 14,697 patients with coronary heart disease. Am J Cardiol. 2003;91:121–127
  12. D'Agostino RB, Russell MW, Huse DM, et al. Primary and subsequent coronary risk appraisal: New results from The Framingham Study. Am Heart J. 2000;139:272–281
  13. Felker GM, Allen LA, Pocock SJ, et al. Red cell distribution width as a novel prognostic marker in heart failure. J Am Coll Cardiol. 2007;50:40–47
  14. Tonelli M, Sacks F, Arnold M, et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation. 2008;117:163–168

 Funding: This study was funded by internal institutional funds.

 Conflict of Interest: BDH, HTM, BSR, and JLA are named as inventors on a patent protecting the risk scores; the authors have no other potential conflicts of interest to report.

 Authorship: All authors had access to the data and played a role in writing this manuscript.

 Trial Registration: Database registry of the Intermountain Heart Collaborative Study: NCT00406185 (ClinicalTrials.gov).

PII: S0002-9343(09)00103-X

doi: 10.1016/j.amjmed.2008.10.043

The American Journal of Medicine
Volume 122, Issue 6 , Pages 550-558 , June 2009

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