The American Journal of Medicine
Volume 122, Issue 6 , Pages 550-558 , June 2009

Exceptional Mortality Prediction by Risk Scores from Common Laboratory Tests

  • Benjamin D. Horne, PhD, MPH

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Genetic Epidemiology Division, Department of Biomedical Informatics, University of Utah, Salt Lake City
    • Corresponding Author InformationRequests for reprints should be addressed to Benjamin D. Horne, PhD, MPH, Cardiovascular Department, Intermountain Medical Center, 5121 S. Cottonwood St, Murray, UT 84157
    • ,
  • Heidi T. May, PhD, MSPH

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • ,
  • Joseph B. Muhlestein, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City
    • ,
  • Brianna S. Ronnow, MS

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • ,
  • Donald L. Lappé, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City
    • ,
  • Dale G. Renlund, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City
    • ,
  • Abdallah G. Kfoury, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • ,
  • John F. Carlquist, PhD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City
    • ,
  • Patrick W. Fisher, DO, PhD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • ,
  • Robert R. Pearson, PharmD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Current address: Clinical Development and Medical Affairs, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709.
    • ,
  • Tami L. Bair, BS

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • ,
  • Jeffrey L. Anderson, MD

      Affiliations

    • Cardiovascular Department, Intermountain Medical Center, Murray, Utah
    • Cardiology Division, Department of Internal Medicine, University of Utah, Salt Lake City

  • Image Result

    Risk stratification for death in the test (A) and NHANES III (B) populations by the 1- and 5-year Intermountain Risk Scores. Sample sizes across the risk scores approximated the normal distribution.

    Risk stratification for death in the test (A) and NHANES III (B) populations by the 1- and 5-year Intermountain Risk Scores. Sample sizes across the risk scores approximated the normal distribution.

  • Image Result

    Relative risks of death based on risk categories from Table 4: low risk (less than high-sensitivity threshold), moderate risk (high-sensitivity threshold or greater and less than high-specificity thre

    Relative risks of death based on risk categories from Table 4: low risk (less than high-sensitivity threshold), moderate risk (high-sensitivity threshold or greater and less than high-specificity threshold), and high risk (high-specificity threshold or greater). Test (A), NHANES III (B), and angiography (C) populations. When fully adjusted for risk factors, comorbidities, and treatments, angiography patient relative risks were as follows: 30 days, 3.24 (P = .030) and 13.80 (P <.001); 1 year, 2.02 (P = .017) and 8.62 (P <.001). The low-risk category is the referent, and the x-axes are on a logarithmic scale.

 Funding: This study was funded by internal institutional funds.

 Conflict of Interest: BDH, HTM, BSR, and JLA are named as inventors on a patent protecting the risk scores; the authors have no other potential conflicts of interest to report.

 Authorship: All authors had access to the data and played a role in writing this manuscript.

 Trial Registration: Database registry of the Intermountain Heart Collaborative Study: NCT00406185 (ClinicalTrials.gov).

PII: S0002-9343(09)00103-X

doi: 10.1016/j.amjmed.2008.10.043

The American Journal of Medicine
Volume 122, Issue 6 , Pages 550-558 , June 2009

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