The American Journal of Medicine
Volume 122, Issue 6 , Pages 566-573 , June 2009

Cystatin C in Acute Heart Failure Without Advanced Renal Impairment

  • Hiroyuki Naruse, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
  • ,
  • Junnichi Ishii, MD

      Affiliations

    • Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University School of Medicine, Toyoake, Japan
    • Corresponding Author InformationRequests for reprints should be addressed to Junnichi Ishii, MD, Department of Joint Research Laboratory of Clinical Medicine, Fujita Health University School of Medicine, 1-98 Kutsukake-cho, Dengakugakubo, Toyoake 470-1192, Japan
  • ,
  • Tomoko Kawai, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
  • ,
  • Kousuke Hattori, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
  • ,
  • Makoto Ishikawa, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
  • ,
  • Masanori Okumura, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
  • ,
  • Shino Kan, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
  • ,
  • Tadashi Nakano, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
  • ,
  • Shigeru Matsui, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
  • ,
  • Masanori Nomura, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
  • ,
  • Hitoshi Hishida, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan
  • ,
  • Yukio Ozaki, MD

      Affiliations

    • Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Japan

References 

  1. Go AS, Chertow GM, Fan D. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296–1305
  2. Manjunath G, Tighiouart H, Ibrahim H, et al. Level of kidney function as a risk factor for atherosclerotic cardiovascular outcomes in the community. J Am Coll Cardiol. 2003;41:47–55
  3. Rahman M, Pressel S, Davis BR, et al. Cardiovascular outcomes in high-risk hypertensive patients stratified by baseline glomerular filtration rate. Ann Intern Med. 2006;144:172–180
  4. Sarnak MJ, Levey AS, Schoolwerth AC, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003;108:2154–2169
  5. Sherman DS, Fish DN, Teitelbaum I. Assessing renal function in cirrhotic patients: problems and pitfalls. Am J Kidney Dis. 2003;41(2):269–278
  6. Levey AS, Bosch JP, Lewis JB. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation (Modification of Diet in Renal Disease Study Group). Ann Intern Med. 1999;130:461–470
  7. Lewis J, Agodoa L, Cheek D, et al. Comparison of cross-sectional renal function measurements in African Americans with hypertensive nephrosclerosis and of primary formulas to estimate glomerular filtration rate. Am J Kidney Dis. 2001;38:744–753
  8. Imai E, Horio M, Nitta K, et al. Modification of the Modification of Diet in Renal Disease (MDRD) Study equation for Japan. Am J Kidney Dis. 2007;50:927–937
  9. Coll E, Botey A, Alvarez L, et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis. 2000;36:29–34
  10. Fliser D, Ritz E. Serum cystatin C concentration as a marker of renal dysfunction in the elderly. Am J Kidney Dis. 2001;37:79–83
  11. Abrahamson M, Olafsson I, Palsdottir A, et al. Structure and expression of the human cystatin C gene. Biochem J. 1990;268:287–294
  12. Jernberg T, Lindahl B, James S, et al. Cystatin C: a novel predictor of outcome in suspected or confirmed non-ST-elevation acute coronary syndrome. Circulation. 2004;110:2342–2348
  13. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39(2):S1–S266
  14. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143:29–36
  15. Pucci L, Triscornia S, Lucchesi D, et al. Cystatin C and estimates of renal function: searching for a better measure of kidney function in diabetic patients. Clin Chem. 2007;53:480–488
  16. Mussap M, Dalla Vestra M, Fioretto P, et al. Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients. Kidney Int. 2002;61:1453–1461
  17. Stevens LA, Coresh J, Greene T, et al. Assessing kidney function—measured and estimated glomerular filtration rate. N Engl J Med. 2006;354:2473–2483
  18. Stevens LA, Coresh J, Schmid CH, et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis. 2008;51:395–406
  19. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145:247–254
  20. Lassus J, Harjola VP, Sund R, et al. Prognostic value of cystatin C in acute heart failure in relation to other markers of renal function and NT-proBNP. Eur Heart J. 2007;28:1841–1847
  21. Parameshwar J, Keegan J, Sparrow J, et al. Predictors of prognosis in severe chronic heart failure. Am Heart J. 1992;123:421–426
  22. Cintron G, Johnson G, Francis G, et al. Prognostic significance of serial changes in left ventricular ejection fraction in patients with congestive heart failure (The V-HeFT VA Cooperative Studies Group). Circulation. 1993;87:VI17–VI23
  23. Judge KW, Pawitan Y, Caldwell J, et al. Congestive heart failure symptoms in patients with preserved left ventricular systolic function: analysis of the CASS registry. J Am Coll Cardiol. 1991;18:377–382
  24. Setaro JF, Soufer R, Remetz MS, et al. Long-term outcome in patients with congestive heart failure and intact systolic left ventricular performance. Am J Cardiol. 1992;69:1212–1216
  25. Carson P, Johnson G, Fletcher R, et al. Mild systolic dysfunction in heart failure (left ventricular ejection fraction >35%): baseline characteristics, prognosis and response to therapy in the Vasodilator in Heart Failure Trials (V-HeFT). J Am Coll Cardiol. 1996;27:642–649
  26. Jones RC, Francis GS, Lauer MS. Predictors of mortality in patients with heart failure and preserved systolic function in the Digitalis Investigation Group trial. J Am Coll Cardiol. 2004;44:1025–1029
  27. Fonarow GC, Stough WG, Abraham WT, et al. Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry. J Am Coll Cardiol. 2007;50:768–777
  28. European Study Group on Diastolic Heart Failure. How to diagnose diastolic heart failure. Eur Heart J. 1998;19:990–1003
  29. Knight EL, Verhave JC, Spiegelman D, et al. Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney Int. 2004;65:1416–1421
  30. Laterza OF, Price CP, Scott MG. Cystatin C: an improved estimator of glomerular filtration rate?. Clin Chem. 2002;48:699–707
  31. Shlipak MG, Sarnak MJ, Katz R, et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med. 2005;352:2049–2060
  32. Newman DJ. Cystatin C. Ann Clin Biochem. 2002;39(Pt 2):89–104
  33. Kazama JJ, Kutsuwada K, Ataka K, et al. Serum cystatin C reliably detects renal dysfunction in patients with various renal diseases. Nephron. 2002;91:13–20
  34. Heywood J, Fonarow G, Costanzo M, et al. High prevalence of renal dysfunction and its impact on outcome in 118465 patients hospitalizes with acute decompensated heart failure: a report from the ADHERE database. J Cardiac Fail. 2007;13:422–430
  35. Smith GL, Lichtman JH, Bracken MB, et al. Renal impairment and outcomes in heart failure: systematic review and meta-analysis. J Am Coll Cardiol. 2006;47:1987–1996

 Funding: None.

 Conflict of Interest: None.

 Authorship: We verify that all authors had access to the data and a role in writing the manuscript.

PII: S0002-9343(09)00102-8

doi: 10.1016/j.amjmed.2008.10.042

The American Journal of Medicine
Volume 122, Issue 6 , Pages 566-573 , June 2009