The American Journal of Medicine
Volume 122, Issue 6 , Pages 574-580 , June 2009

Hypotension Unawareness in Profound Orthostatic Hypotension

  • Steven D. Arbogast, DO

      Affiliations

    • Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio
    • Corresponding Author InformationRequests for reprints should be addressed to Steven Arbogast, DO, Neurologic Institute, University Hospitals Case Medical Center, 11100 Euclid Ave., Cleveland, OH 44106
    • ,
  • Amer Alshekhlee, MD, MS

      Affiliations

    • Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio
    • ,
  • Zulfiqar Hussain, MD

      Affiliations

    • Robert Wood Johnson Medical School/University Hospital, UMDNJ, New Brunswick, NJ
    • ,
  • Kevin McNeeley

      Affiliations

    • Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio
    • ,
  • Thomas C. Chelimsky, MD

      Affiliations

    • Autonomic Laboratory, Neurologic Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio

References 

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  2. Weimer LH, Williams O. Syncope and orthostatic intolerance. Med Clin North Am. 2003;87(4):835–865
  3. Eigenbrodt ML, Rose KM, Couper DJ, et al. Orthostatic hypotension as a risk factor for stroke: the atherosclerosis risk in communities (ARIC) study, 1987-1996. Stroke. 2000;31(10):2307–2313
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  5. Masaki KH, Schatz IJ, Burchfiel CM, et al. Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program. Circulation. 1998;98(21):2290–2295
  6. Rose KM, Eigenbrodt ML, Biga RL, et al. Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk In Communities (ARIC) Study. Circulation. 2006;114(7):630–636
  7. Gibbons CH, Freeman R. Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance. Neurology. 2006;67(1):28–32
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  9. Lahrmann H, Cortelli P, Hilz M, et al. EFNS guidelines on the diagnosis and management of orthostatic hypotension. Eur J Neurol. 2006;13(9):930–936
  10. Brignole M, Alboni P, Benditt DG, et al. Guidelines on management (diagnosis and treatment) of syncope—update 2004. Europace. 2004;6(6):467–537
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  13. Chu LW, Chi I, Chiu AY. Incidence and predictors of falls in the Chinese elderly. Ann Acad Med Singapore. 2005;34(1):60–72
  14. Tromp AM, Pluijm SM, Smit JH, et al. Fall-risk screening test: a prospective study on predictors for falls in community-dwelling elderly. J Clin Epidemiol. 2001;54(8):837–844
  15. Luukinen H, Koski K, Kivela SL, Laippala P. Social status, life changes, housing conditions, health, functional abilities and life-style as risk factors for recurrent falls among the home-dwelling elderly. Public Health. 1996;110(2):115–118
  16. Campbell AJ, Borrie MJ, Spears GF. Risk factors for falls in a community-based prospective study of people 70 years and older. J Gerontol. 1989;44(4):M112–M117
  17. Pavy-Le Traon A, Hughson RL, Thalamas C, et al. Cerebral autoregulation is preserved in multiple system atrophy: a transcranial Doppler study. Mov Disord. 2006;21(12):2122–2126

 Funding: Funding was not required for this project.

 Conflict of Interest: None of the authors have conflicts of interest or financial disclosures to make.

 Authorship: All authors had full access to the data in the study and take responsibility for the integrity of the data and the accuracy of the analysis. All authors had a role in the writing of the manuscript.

PII: S0002-9343(09)00098-9

doi: 10.1016/j.amjmed.2008.10.040

The American Journal of Medicine
Volume 122, Issue 6 , Pages 574-580 , June 2009

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