The American Journal of Medicine
Volume 122, Issue 1, Supplement , Pages S3-S14 , January 2009

The Pathology of Atherosclerosis: Plaque Development and Plaque Responses to Medical Treatment

  • William Insull Jr., MD

      Affiliations

    • Corresponding Author InformationRequests for reprints should be addressed to William Insull, Jr., MD, Lipid Research Clinic, Baylor Faculty Center, 1709 Dryden Road, Suite 08.08, Houston, Texas 77030-3411

  • Image Result

    Histologic examples of 4 atherosclerotic plaque types. (A) Coronary fibrous cap atheroma in a 24-year-old man. (B) Thin fibrous cap atheroma. (C) Healed plaque rupture. (D) Stenosis of the anterior de

    Histologic examples of 4 atherosclerotic plaque types. (A) Coronary fibrous cap atheroma in a 24-year-old man. (B) Thin fibrous cap atheroma. (C) Healed plaque rupture. (D) Stenosis of the anterior descending coronary artery in a 40-year-old man. (Reprinted with permission from Atlas of Atherosclerosis: Progression and Regression11 and Arterioscler Thromb Vasc Biol.12)

  • Image Result
    Histologic examples of 4 atherosclerotic plaque types. (A) Coronary fibrous cap atheroma in a 24-year-old man. (B) Thin fibrous cap atheroma. (C) Healed plaque rupture. (D) Stenosis of the anterior de

    Histologic examples of 4 atherosclerotic plaque types. (A) Coronary fibrous cap atheroma in a 24-year-old man. (B) Thin fibrous cap atheroma. (C) Healed plaque rupture. (D) Stenosis of the anterior descending coronary artery in a 40-year-old man. (Reprinted with permission from Atlas of Atherosclerosis: Progression and Regression11 and Arterioscler Thromb Vasc Biol.12)

  • Image Result
    Increasing extent of atherosclerotic plaques with age. CVD = cardiovascular disease; LAD = left anterior descending. (Adapted with permission from Lab Invest.1)

    Increasing extent of atherosclerotic plaques with age. CVD = cardiovascular disease; LAD = left anterior descending. (Adapted with permission from Lab Invest.1)

  • Image Result
    Flow chart of the general concepts of the development of atherosclerosis. ACS = acute coronary syndromes. (Adapted with permission from Arterioscler Thromb Vasc Biol.12)

    Flow chart of the general concepts of the development of atherosclerosis. ACS = acute coronary syndromes. (Adapted with permission from Arterioscler Thromb Vasc Biol.12)

  • Image Result
    Influence of therapeutic intervention on the atherosclerotic process.

    Influence of therapeutic intervention on the atherosclerotic process.

 Statement of author disclosure: Please see the Author Disclosures section at the end of this article.

 To access a slide kit for this article, please click here.

PII: S0002-9343(08)01017-6

doi: 10.1016/j.amjmed.2008.10.013

The American Journal of Medicine
Volume 122, Issue 1, Supplement , Pages S3-S14 , January 2009

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