The American Journal of Medicine
Volume 122, Issue 3 , Pages 265-272 , March 2009

B-Type Natriuretic Peptides for the Evaluation of Exercise Intolerance

  • Christian Mueller, MD

      Affiliations

    • Department of Internal Medicine, University Hospital Basel, Switzerland
    • Corresponding Author InformationRequests for reprints should be addressed to Christian Mueller, MD, FESC, Department of Internal Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland
    • ,
  • Micha T. Maeder, MD

      Affiliations

    • Department of Cardiology, University Hospital Basel, Switzerland
    • ,
  • Andreas Christ, MD

      Affiliations

    • Department of Internal Medicine, University Hospital Basel, Switzerland
    • ,
  • Tobias Reichlin, MD

      Affiliations

    • Department of Internal Medicine, University Hospital Basel, Switzerland
    • ,
  • Daniel Staub, MD

      Affiliations

    • Department of Internal Medicine, University Hospital Basel, Switzerland
    • ,
  • Markus Noveanu, MD

      Affiliations

    • Department of Internal Medicine, University Hospital Basel, Switzerland
    • ,
  • Tobias Breidthardt, MD

      Affiliations

    • Department of Internal Medicine, University Hospital Basel, Switzerland
    • ,
  • Mihael Potocki, MD

      Affiliations

    • Department of Internal Medicine, University Hospital Basel, Switzerland
    • ,
  • Martin H. Brutsche, MD, PhD

      Affiliations

    • Division of Pulmonary Care, University Hospital Basel, Switzerland

  • Image Result

    Receiver operating characteristic (ROC) curves for the ability of B-type natriuretic peptide (BNP) and N-terminal-pro-B-type-natriuretic peptide (NT-proBNP) measured at rest to detect a cardiocirculat

    Receiver operating characteristic (ROC) curves for the ability of B-type natriuretic peptide (BNP) and N-terminal-pro-B-type-natriuretic peptide (NT-proBNP) measured at rest to detect a cardiocirculatory limitation. The area under the ROC curve (AUC) with 95% confidence interval (CI) is given.

  • Image Result
    Receiver operating characteristic (ROC) curves for the ability of B-type natriuretic peptide (BNP) and N-terminal-pro-B-type-natriuretic peptide (NT-proBNP) measured at peak exercise to detect a cardi

    Receiver operating characteristic (ROC) curves for the ability of B-type natriuretic peptide (BNP) and N-terminal-pro-B-type-natriuretic peptide (NT-proBNP) measured at peak exercise to detect a cardiocirculatory limitation. The area under the ROC curve (AUC) with 95% confidence interval (CI) is given.

 Funding: CM (Grant PP00B-102853) and MTM (Grant PBZHB-121007) are supported by the Swiss National Science Foundation.

 Conflicts of Interest: Dr. Mueller has received research support from Abbott, Biosite, Brahms, and Roche as well as speaker's honoraria from Abbott, Bayer, Biosite, Brahms, and Roche Diagnostic. The other authors have no possible conflicts of interest to declare. Diagnostic reagents were provided by Roche Diagnostics (Basel, Switzerland) and Abbott (Zug, Switzerland). The sponsors had no role in study design, data analysis, or interpretation.

 Authorship: All authors had access to the data and played a role in writing this manuscript.

PII: S0002-9343(08)00986-8

doi: 10.1016/j.amjmed.2008.08.030

The American Journal of Medicine
Volume 122, Issue 3 , Pages 265-272 , March 2009

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