The American Journal of Medicine
Volume 122, Issue 2 , Pages 144-151 , February 2009

Predictors and Implications of Q-Waves in ST-Elevation Acute Coronary Syndromes

  • Troy LaBounty, MD

      Affiliations

    • Weill Cornell Medical College, New York, NY
    • ,
  • Hitinder S. Gurm, MD

      Affiliations

    • University of Michigan, Ann Arbor, Mich
    • Ann Arbor Veterans Administration Hospital, Ann Arbor, Mich
    • ,
  • Shaun G. Goodman, MD

      Affiliations

    • Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, Ontario, Canada
    • Canadian Heart Research Centre, Toronto, Ontario, Canada
    • ,
  • Gilles Montalescot, MD, PhD

      Affiliations

    • Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France
    • ,
  • Jose Lopez-Sendon, MD

      Affiliations

    • Hospital Universitario La Paz, Madrid, Spain
    • ,
  • Ann Quill, MA

      Affiliations

    • University of Massachusetts, Worcester
    • ,
  • Kim A. Eagle, MD

      Affiliations

    • University of Michigan, Ann Arbor, Mich
    • Corresponding Author InformationRequests for reprints should be addressed to Kim A Eagle, MD, Cardiovascular Center, University of Michigan, 1500 East Medical Center Drive, Room 2135-B, Ann Arbor, MI 48109-5852
    • ,
  • GRACE Investigators

  • Image Result

    Variables associated with Q-waves on the initial ECG (n=10,939). ECG=electrocardiogram; OR=odds ratio; CI = confidence interval; other meds=beta-blocker, angiotensin-converting enzyme inhibitor or rec

    Variables associated with Q-waves on the initial ECG (n=10,939). ECG=electrocardiogram; OR=odds ratio; CI = confidence interval; other meds=beta-blocker, angiotensin-converting enzyme inhibitor or receptor blocker, or statin versus none. OR for increased age per 5 years.

  • Image Result
    Variables associated with new-onset Q-waves after initial 24 hours (n=7404). OR=odds ratio; CI=confidence interval.

    Variables associated with new-onset Q-waves after initial 24 hours (n=7404). OR=odds ratio; CI=confidence interval.

  • Image Result
    Presenting variables associated with in-hospital mortality (n=13,160). Presenting Q-waves were independently associated with increased in-hospital mortality. OR=odds ratio; CI=confidence interval. OR

    Presenting variables associated with in-hospital mortality (n=13,160). Presenting Q-waves were independently associated with increased in-hospital mortality. OR=odds ratio; CI=confidence interval. OR for increased age per 5 years, for systolic blood pressure per 5 mm Hg, for pulse per 5 beats per minute, and for creatinine per 1 mg/dL.

 Funding: This research was supported by an unrestricted grant from Sanofi-Aventis, Paris, France. The Global Registry of Acute Coronary Events is supported by an unrestricted educational grant from Sanofi-Aventis to the Center for Outcomes Research, University of Massachusetts Medical School. Sanofi-Aventis had no involvement in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication. The design, conduction, and interpretation were undertaken by an independent steering committee.

 Conflict of Interest: There are no other conflicts of interest for any of the authors.

 Authorship: All authors meet criteria for authorship including access to the data and all authors had a role in the writing of the manuscript.

PII: S0002-9343(08)00980-7

doi: 10.1016/j.amjmed.2008.08.029

The American Journal of Medicine
Volume 122, Issue 2 , Pages 144-151 , February 2009

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