The American Journal of Medicine
Volume 122, Issue 2 , Pages 162.e1-162.e9 , February 2009

“Dose-dependent” Impact of Recurrent Cardiac Events on Mortality in Patients with Heart Failure

  • Douglas S. Lee, MD, PhD

      Affiliations

    • Institute for Clinical Evaluative Sciences, Toronto, Ont, Canada
    • Division of Cardiology of University Health Network and Mt. Sinai Hospital, Toronto, Ont, Canada
    • Corresponding Author InformationRequests for reprints should be addressed to Douglas S. Lee, MD, PhD, Institute for Clinical Evaluative Sciences, Rm G-106, 2075 Bayview Ave., Toronto, ON, Canada
    • ,
  • Peter C. Austin, PhD

      Affiliations

    • Institute for Clinical Evaluative Sciences, Toronto, Ont, Canada
    • Department of Health Policy, Management and Evaluation, Toronto, Ont, Canada
    • ,
  • Thérèse A. Stukel, PhD

      Affiliations

    • Institute for Clinical Evaluative Sciences, Toronto, Ont, Canada
    • Department of Health Policy, Management and Evaluation, Toronto, Ont, Canada
    • ,
  • David A. Alter, MD, PhD

      Affiliations

    • Institute for Clinical Evaluative Sciences, Toronto, Ont, Canada
    • Department of Health Policy, Management and Evaluation, Toronto, Ont, Canada
    • Division of Cardiology of St. Michael's Hospital, Toronto, Ont, Canada
    • ,
  • Alice Chong, BSc

      Affiliations

    • Institute for Clinical Evaluative Sciences, Toronto, Ont, Canada
    • ,
  • John D. Parker, MD

      Affiliations

    • Division of Cardiology of University Health Network and Mt. Sinai Hospital, Toronto, Ont, Canada
    • ,
  • Jack V. Tu, MD, PhD

      Affiliations

    • Institute for Clinical Evaluative Sciences, Toronto, Ont, Canada
    • Department of Health Policy, Management and Evaluation, Toronto, Ont, Canada
    • Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Ont, Canada

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 Funding: This research was supported by a Canadian Institutes of Health Research (CIHR) grant and a CIHR Team Grant in Cardiovascular Outcomes Research, a clinician-scientist (DSL) and new investigator award (PCA) from the CIHR, career investigator awards from the Heart and Stroke Foundation of Ontario (JVT, DAA), and a Canada Research Chair in health services research (JVT).

 Conflict of Interest: The authors have no conflict of interest to disclose.

 Authorship: All co-authors had access to the data and contributed to the manuscript.

PII: S0002-9343(08)00958-3

doi: 10.1016/j.amjmed.2008.08.026

The American Journal of Medicine
Volume 122, Issue 2 , Pages 162.e1-162.e9 , February 2009

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