The American Journal of Medicine
Volume 122, Issue 1 , Pages 24-26 , January 2009

Worth a Second Look

  • David Goldberg, MD

      Affiliations

    • Deparment of Medicine, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY
    • Corresponding Author InformationRequests for reprints should be addressed to David Goldberg, MD, 220 West Rittenhouse Square, Apt 8D, Philadelphia, PA 19103
    • ,
  • Ilan Weisberg, MD

      Affiliations

    • Department of Gastroenterology, New York Presbyterian Hospital-Weill-Cornell Medical Center, New York, NY
    • ,
  • David Diuguid, MD

      Affiliations

    • Deparment of Hematology, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY
    • ,
  • Paul Gaglio, MD

      Affiliations

    • Department of Gastroenterology, Albert Einstein College of Medicine-Montefiore Medical Center, New York, NY
    • ,
  • Bachir Alobeid, MD

      Affiliations

    • Deparment of Pathology, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY
    • ,
  • Scott Fink, MD

      Affiliations

    • Department of Gastroenterology, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY
    • ,
  • Jai Radhakrishnan, MD

      Affiliations

    • Department of Nephrology, New York Presbyterian Hospital-Columbia University Medical Center, New York, NY

References 

  1. Choufani EB, Sanchorawala V, Ernst T, et al. Acquired factor X deficiency in patients with amyloid light-chain amyloidosis: incidence, bleeding manifestations, and response to high-dose chemotherapy. Blood. 2001;97:1885–1887
  2. Uprichard J, Perry DJ. Factor X deficiency. Blood Rev. 2002;16:97–110
  3. Eulitz M, Weiss DT, Solomon A. Immunoglobulin heavy-chain-associated amyloidosis. Proc Natl Acad Sci USA. 1990;87:6542–6546
  4. Perfetti V, Garini P, Vignarelli MC, et al. Diagnostic approach to and follow-up of difficult cases of AL amyloidosis. Haematologica. 1995;80:409–415
  5. Gertz MA, Comenzo R, Falk RH, et al. Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004. Am J of Hematol. 2005;79:319–328
  6. Gertz MA, Kyle RA. Primary systemic amyloidosis—a diagnostic primer. Mayo Clin Proc. 1989;64:1505–1519
  7. Gertz MA, Kyle RA. Hepatic amyloidosis (primary [AL], immunoglobulin light chain): the matural history in 80 patients. Am J Med. 1988;85:73–80
  8. Levy M, Fryd CH, Eliakim M. Intrahepatic obstructive jaundice due to amyloidosis of the liver (A case report and review of the literature). Gastroenterology. 1971;61:234–238
  9. Park MA, Mueller PS, Kyle RA, et al. Primary (AL) hepatic amyloidosis: clinical features and natural history in 98 patients. Medicine (Baltimore). 2003;82:291–298
  10. Girmann G, Wilker D, Stadie H, Scheurlen PG. Acquired isolated factor X deficiency associated with systemic amyloidosis (Case report and review of literature). Klin Wochenschr. 1980;58:859–862
  11. Furie B, Voo L, McAdam KP, Furie BC. Mechanism of factor X deficiency in systemic amyloidosis. N Engl J Med. 1981;304:827–830
  12. Fair DS, Edgington TS. Heterogeneity of hereditary and acquired factor X deficiencies by combined immunochemical and functional analyses. Br J Haematol. 1985;59:235–248
  13. Comenzo RL. Managing systemic light-chain amyloidosis. J Natl Compr Canc Netw. 2007;5:179–187
  14. Jaccard A, Moreau P, Leblond V, et al. Myélome Autogreffe (MAG) and Intergroupe Francophone du Myélome (IFM) Intergroup High-dose melphalan versus melphalan plus dexamethasone for AL amyloidosis. N Engl J Med. 2007;357:1083–1093

 Charles M. Wiener, MD, Section Editor

 Funding: None.

 Conflict of Interest: None of the authors have any conflict of interests to report as it relates to the submission of this manuscript.

 Authorship: This work is original, all of the authors meet the criteria for authorship, including acceptance of responsibility for the scientific content of the manuscript.

PII: S0002-9343(08)00887-5

doi: 10.1016/j.amjmed.2008.09.015

The American Journal of Medicine
Volume 122, Issue 1 , Pages 24-26 , January 2009

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