The American Journal of Medicine
Volume 121, Issue 12 , Pages 1072-1077 , December 2008

Iron Status and Colorectal Cancer in Symptomatic Elderly Patients

  • Etienne Joosten, MD, PhD

      Affiliations

    • Department of Internal Medicine, Division of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium
    • Corresponding Author InformationRequests for reprints should be addressed to Etienne Joosten, MD, PhD, Department of Internal Medicine, Division of Geriatric Medicine, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium
  • ,
  • Joris Meeuwissen, MD

      Affiliations

    • Department of Internal Medicine, Division of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium
  • ,
  • Hannelore Vandewinckele, MD

      Affiliations

    • Department of Internal Medicine, Division of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium
  • ,
  • Martin Hiele, MD, PhD

      Affiliations

    • Department of Internal Medicine, Division of Gastroenterology, University Hospitals Leuven, Leuven, Belgium

References 

  1. Sawhney MS, Lipato T, Nelson DB, et al. Should patients with anemia and low normal or normal serum ferritin undergo colonoscopy?. Am J Gastroenterol. 2007;102:82–88
  2. Wang SA, Fadare O, Nagar A, et al. Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values. Am J Hematol. 2006;81:324–327
  3. Joosten E, Hiele M, Ghoos Y, et al. Diagnosis of iron-deficiency anemia in a hospitalized geriatric population. Am J Med. 1991;90:653–654
  4. Joosten E, Ghesquiere B, Linthoudt H, et al. Upper and lower gastrointestinal evaluation of elderly inpatients who are iron deficient. Am J Med. 1999;107:24–29
  5. Lin OS, Kozarek RA, Schembre DB, et al. Screening colonoscopy in very elderly patients (Prevalence of neoplasia and estimated impact on life expectancy). JAMA. 2006;295:2357–2365
  6. Stevens T, Burke CA. Colonoscopy screening in the elderly: when to stop?. Am J Gastroenterol. 2003;98:1881–1885
  7. Ioannou GN, Rockey DC, Bryson CL, Weiss NS. Iron deficiency and gastrointestinal malignancy: a population-based cohort study. Am J Med. 2002;113:276–280
  8. Arora A, Singh P. Colonoscopy in patients 80 years of age and older is safe, with high success rate and diagnostic yield. Gastrointest Endosc. 2004;60:408–413
  9. Strul H, Kariv R, Leshno M, et al. The prevalence rate and anatomic location of colorectal adenoma and cancer detected by colonoscopy in average-risk individuals aged 40-80 years. Am J Gastroenterol. 2006;101:255–262
  10. Syn WK, Tandon U, Ahmed MM. Colonoscopy in the very elderly is safe and worthwhile. Age Ageing. 2005;34:510–513
  11. Cardin F, Barbato B, Terranova O. Outcomes of safe, simple colonoscopy in older adults. Age Ageing. 2005;34:513–515
  12. Duncan JE, Sweeney WB, Trudel JL, et al. Colonoscopy in the elderly: low risk, low yield in asymptomatic patients. Dis Colon Rectum. 2006;49:646–651
  13. Sardinha TC, Noqueras JJ, Ehrenpreis ED, et al. Colonoscopy in octogenarians: a review of 428 cases. Int J Colorectal Dis. 1999;14:172–176
  14. Imperiale TF, Wagner DR, Lin CY, et al. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med. 2000;343:169–174
  15. Lieberman DA, Weiss DG, Bond JH, et al. Use of colonoscopy to screen asymptomatic adults for colorectal cancer. N Engl J Med. 2000;343:162–168
  16. Stephens MR, Hopper AN, White SR, et al. Colonoscopy first for iron deficiency anaemia: a numbers needed to investigate approach. Q J Med. 2006;99:389–395
  17. Lee JG, Sahagun G, Oehlke MA, Lieberman DA. Serious gastrointestinal pathology found in patients with serum ferritin values ≤50 ng/ml. Am J Gastroenterol. 1998;93:772–776
  18. James MW, Chen CM, Goddard WP, et al. Risk factors for gastrointestinal malignancy in patients with iron deficiency anaemia. Eur J Gastroenterol Hepatol. 2005;17:1197–1203
  19. Scholefield JH, Robinson MH, Bostock K, Brown NS. Serum ferritin (Screening test for colorectal cancer?). Dis Colon Rectum. 1998;41:1029–1031
  20. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011–1023
  21. Acher PL, Al-Mishlab T, Rahman M, Bates T. Iron-deficiency anaemia and delay in the diagnosis of colorectal cancer. Colorectal Dis. 2003;5:145–148
  22. Beale AL, Penny MD, Allisson MC. The prevalence of iron deficiency among patients presenting with colorectal cancer. Colorectal Dis. 2005;7:398–402

PII: S0002-9343(08)00791-2

doi: 10.1016/j.amjmed.2008.06.039

The American Journal of Medicine
Volume 121, Issue 12 , Pages 1072-1077 , December 2008